Ding Wenbing, Huang Rui, Zhou Zhongshi, Li Youzhi
Hunan Provincial Engineering & Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China.
National Research Center of Engineering & Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China.
Molecules. 2015 Mar 10;20(3):4450-9. doi: 10.3390/molecules20034450.
A new pseudoguaianolide 1 and two new guaiane-type sesquiterpene glucosides 2 and 3, were isolated from the aerial parts of Ambrosia artemisiifolia L together with two known sesquiterpene dilactones 4 and 5. The new compounds were determined on the basis of spectroscopic and chemical methods to be 3β-acetoxy-4β-hydroxy-1α,7α, 10β,11αH-pseudoguaia-12,8β-olide (1), 1β,7β,9β,10β,13αH-guaia-4(5)-en-12,6β-olide 9-O-β-d-glucoside (2) and 4β-hydroxy-1α,5α,7α,9αH-guaia-10(14),11(13)-dien-12-acid 9-O-β-d-glucoside (3). The isolated compounds were evaluated for cytotoxicity against human promyelocytic leukemia HL-60 cell lines in vitro, but were all inactive.
从豚草地上部分分离得到一个新的伪愈创木内酯1以及两个新的愈创木烷型倍半萜糖苷2和3，同时还得到两个已知的倍半萜双内酯4和5。通过光谱和化学方法确定新化合物分别为3β-乙酰氧基-4β-羟基-1α,7α,10β,11αH-伪愈创木-12,8β-内酯（1）、1β,7β,9β,10β,13αH-愈创木-4(5)-烯-12,6β-内酯9-O-β-D-葡萄糖苷（2）和4β-羟基-1α,5α,7α,9αH-愈创木-10(14),11(13)-二烯-12-酸9-O-β-D-葡萄糖苷（3）。对分离得到的化合物进行了体外抗人早幼粒细胞白血病HL-60细胞系的细胞毒性评价，但所有化合物均无活性。
