Yoshimura Aya, Ohnishi Shunsuke, Orito Chieko, Kawahara Yukako, Takasaki Hiroyo, Takeda Hiroshi, Sakamoto Naoya, Hashino Satoshi
Health Care Center, Hokkaido University, Sapporo, Japan.
Obes Facts. 2015;8(1):1-16. doi: 10.1159/000373881. Epub 2015 Jan 29.
Obesity has been demonstrated to be associated with elevated leukocytes in adults and children. This study assessed the associations between peripheral total and differential leukocyte counts and obesity-related complications in young adults.
12 obese (median age 21.5 (range 19-28) years, median BMI 35.7 (range 32.0-44.9) kg/m(2)) and 11 normal (median age 23 (range 18-27) years, median BMI 19.5 (range 18.1-21.7) kg/m(2)) adults were enrolled. Complete blood count and serum levels of liver enzymes, fasting blood glucose, insulin and lipids were measured, and the homeostasis model assessment of insulin resistance was calculated. Fat mass was calculated using a bioimpedance analysis device, and ultrasonography was performed to measure fat thickness and to detect fatty change of the liver.
Total leukocyte and monocyte counts were significantly increased in obese young adults. Total leukocyte count was associated with liver enzyme levels, insulin resistance as well as visceral and subcutaneous fat thickness. Neutrophil count was associated with insulin resistance. Lymphocyte count was associated with serum liver enzymes, insulin resistance, and dyslipidemia. Monocyte count was associated with serum liver enzyme, insulin resistance, visceral and subcutaneous fat thickness, body fat mass, and percentage body fat.
The results of this study suggest that chronic low-grade systemic inflammation is associated with obesity-related complications such as nonalcoholic fatty liver disease, insulin resistance, and dyslipidemia in young adults.
肥胖已被证明与成人及儿童白细胞升高有关。本研究评估了年轻成人外周血白细胞总数及分类计数与肥胖相关并发症之间的关联。
纳入12名肥胖成人（中位年龄21.5岁（范围19 - 28岁），中位BMI 35.7（范围32.0 - 44.9）kg/m²）和11名正常成人（中位年龄23岁（范围18 - 27岁），中位BMI 19.5（范围18.1 - 21.7）kg/m²）。检测全血细胞计数及血清肝酶、空腹血糖、胰岛素和血脂水平，并计算胰岛素抵抗的稳态模型评估值。使用生物电阻抗分析仪计算脂肪量，并进行超声检查以测量脂肪厚度和检测肝脏脂肪变性。
肥胖年轻成人的白细胞总数和单核细胞计数显著增加。白细胞总数与肝酶水平、胰岛素抵抗以及内脏和皮下脂肪厚度相关。中性粒细胞计数与胰岛素抵抗相关。淋巴细胞计数与血清肝酶、胰岛素抵抗和血脂异常相关。单核细胞计数与血清肝酶、胰岛素抵抗、内脏和皮下脂肪厚度、体脂肪量及体脂百分比相关。
本研究结果表明，慢性低度全身炎症与年轻成人肥胖相关并发症如非酒精性脂肪性肝病、胰岛素抵抗和血脂异常有关。
