人类免疫缺陷病毒糖蛋白120与丁丙诺啡身体依赖
HIV-gp120 and physical dependence to buprenorphine.
作者信息
Palma J, Abood M E, Benamar K
机构信息
Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, United States.
Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, United States; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, United States.
出版信息
Drug Alcohol Depend. 2015 May 1;150:175-8. doi: 10.1016/j.drugalcdep.2015.02.021. Epub 2015 Feb 26.
BACKGROUND
Opioids are among the most effective and commonly used analgesics in clinical practice for severe pain. However, the use of opioid medications is clinically limited by several adverse properties including dependence. While opioid dependence is a complex health condition, the treatment of HIV-infected individuals with opioid dependence presents additional challenges. The goal of this study was to examine the physical dependence to buprenorphine in the context of HIV.
METHODS
Young adult male rats (Sprague-Dawley) were pretreated with HIV-1 envelope glycoprotein 120 (gp120) injected into the periaqueductal gray area (PAG) and we examined the impact on physical dependence to opioid.
RESULTS
It was found that the physical dependence to methadone occurred earlier than that to buprenorphine, and that gp120 did not enhance or precipitate the buprenorphine withdrawal.
CONCLUSION
The results suggest that buprenorphine could be the better therapeutic option to manage opioid dependence in HIV.
背景
阿片类药物是临床实践中治疗重度疼痛最有效且常用的镇痛药之一。然而，阿片类药物的使用在临床上受到包括依赖性在内的多种不良特性的限制。虽然阿片类药物依赖是一种复杂的健康状况，但对感染HIV的阿片类药物依赖个体进行治疗面临更多挑战。本研究的目的是在HIV背景下研究对丁丙诺啡的身体依赖性。
方法
将年轻成年雄性大鼠（斯普拉格-道利大鼠）经脑导水管周围灰质区域（PAG）注射HIV-1包膜糖蛋白120（gp120）进行预处理，然后我们研究其对阿片类药物身体依赖性的影响。
结果
发现对美沙酮的身体依赖性比对丁丙诺啡出现得更早，并且gp120不会增强或引发丁丙诺啡戒断反应。
结论
结果表明，丁丙诺啡可能是治疗HIV患者阿片类药物依赖的更好治疗选择。
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