Christopherson W A, Councell R B
Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, PA.
Int J Gynaecol Obstet. 1989 Dec;30(4):379-84. doi: 10.1016/0020-7292(89)90828-x.
Malignant components are present in 1-2% of mature teratomas (dermoid cysts) and historically have been associated with a very poor prognosis. Patients with malignant mature cystic teratomas typically are postmenopausal and may present with a rapidly enlarging tumor or systemic symptoms suggestive of malignancy. However, the diagnosis is rarely made pre-operatively and, if the tumor is not metastatic, may not be made until the tumor is examined microscopically. Squamous cell carcinoma is the most common malignancy found in mature cystic teratomas. We present a 26-year-old woman with this cancer in whom the disease proved fatal. A surgical approach to patients with malignant mature teratomas is suggested. Prognostic factors and adjuvant therapy are discussed.
恶性成分存在于1%-2%的成熟畸胎瘤（皮样囊肿）中，从历史上看，其预后非常差。恶性成熟囊性畸胎瘤患者通常为绝经后女性，可能表现为肿瘤迅速增大或出现提示恶性肿瘤的全身症状。然而，术前很少能做出诊断，而且如果肿瘤没有转移，可能直到对肿瘤进行显微镜检查时才能确诊。鳞状细胞癌是成熟囊性畸胎瘤中最常见的恶性肿瘤。我们报告一名患有这种癌症的26岁女性，该疾病最终导致死亡。本文提出了针对恶性成熟畸胎瘤患者的手术方法。并讨论了预后因素和辅助治疗。
