急性冠状动脉综合征后患者对循证二级预防药物治疗的依从性：一项系统评价。
Adherence to evidence-based secondary prevention pharmacotherapy in patients after an acute coronary syndrome: A systematic review.
作者信息
Chen Han-Yang, Saczynski Jane S, Lapane Kate L, Kiefe Catarina I, Goldberg Robert J
机构信息
Department of Quantitative Health Sciences, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA.
Department of Quantitative Health Sciences, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA; Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA; Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, MA, USA.
出版信息
Heart Lung. 2015 Jul-Aug;44(4):299-308. doi: 10.1016/j.hrtlng.2015.02.004. Epub 2015 Mar 10.
OBJECTIVE
To synthesize current evidence on medication adherence rates and associated risk factors in patients after an acute coronary syndrome (ACS).
METHODS
A systematic review was conducted. Five electronic databases and article bibliographies were searched for publications from 1990 to 2013 which assessed adherence to secondary prevention pharmacotherapy in adults after hospital discharge for an ACS. Identified studies were screened using pre-defined criteria for eligibility. A standardized form was used for data abstraction. Methodological quality was assessed using modified criteria for quantitative studies.
RESULTS
Sixteen studies met our inclusion criteria. Post-discharge medication adherence rates at 1-year ranged between 54% and 86%. There were no consistent predictors of non-adherence across all cardiac medication classes examined.
CONCLUSIONS
Adherence to secondary prevention pharmacotherapy was suboptimal in patients after hospital discharge for an ACS. Risk factors associated with non-adherence were examined in a limited number of studies, and the associations varied between these investigations.
目的
综合目前关于急性冠状动脉综合征（ACS）患者药物依从率及相关危险因素的证据。
方法
进行了一项系统评价。检索了五个电子数据库和文章参考文献，以查找1990年至2013年期间评估ACS出院后成人二级预防药物治疗依从性的出版物。使用预先定义的纳入标准对纳入的研究进行筛选。采用标准化表格进行数据提取。使用修改后的定量研究标准评估方法学质量。
结果
16项研究符合我们的纳入标准。出院后1年的药物治疗依从率在54%至86%之间。在所检查的所有心脏药物类别中，没有一致的不依从预测因素。
结论
ACS出院患者二级预防药物治疗的依从性欠佳。在少数研究中对与不依从相关的危险因素进行了检查，且这些研究之间的关联各不相同。
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