Au Sunny C L, Tang Shu-Min, Rong Shi-Song, Chen Li-Jia, Yam Jason C S
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
Sci Rep. 2015 Mar 13;5:9091. doi: 10.1038/srep09091.
As the role of hyperglycemia in the development of retinopathy of prematurity (ROP) has not been well established, a meta-analysis of the association between hyperglycemia and ROP was conducted. Studies were identified through literature search in MEDLINE and EMBASE up to June 20, 2014 with keywords related to "hyperglycaemia" and "ROP". Nine eligible studies involving 1939 neonates with 509 cases of ROP were included. Unadjusted analyses showed that hyperglycemia was significantly associated with ROP (Odds ratio [OR] = 4.16, P<0.0001). Comparing with the control, subjects in the ROP group had a significantly longer duration of hyperglycemia (Standardized mean difference [SMD] = 1.21, P< 0.0001), and higher mean glucose level. (SMD = 0.88, P = 0.0004) However, when combining the adjusted OR (after adjustment for birth weight, gestational age and other factors) provided from individual studies, only borderline significant association were observed on duration of hyperglycemia with ROP (adjusted OR 1.08, P = 0.03); and no significant association on mean glucose level with ROP (adjusted OR = 1.08, P = 0.15). Hence, hyperglycemia cannot be definitely considered as a risk factor for ROP, and further studies should adjust for potential confounding factors to clarify this association.
由于高血糖在早产儿视网膜病变（ROP）发展中的作用尚未明确确立，因此对高血糖与ROP之间的关联进行了一项荟萃分析。通过检索MEDLINE和EMBASE截至2014年6月20日的文献，使用与“高血糖症”和“ROP”相关的关键词来识别研究。纳入了9项符合条件的研究，涉及1939名新生儿，其中509例患有ROP。未调整分析显示，高血糖与ROP显著相关（优势比[OR]=4.16，P<0.0001）。与对照组相比，ROP组的受试者高血糖持续时间显著更长（标准化平均差[SMD]=1.21，P<0.0001），且平均血糖水平更高（SMD=0.88，P=0.0004）。然而，当合并各个研究提供的调整后OR（在调整出生体重、胎龄和其他因素后）时，仅观察到高血糖持续时间与ROP之间存在边缘显著关联（调整后OR 1.08，P=0.03）；而平均血糖水平与ROP之间无显著关联（调整后OR=1.08，P=0.15）。因此，不能明确将高血糖视为ROP的危险因素，进一步的研究应调整潜在的混杂因素以阐明这种关联。
