Phaechamud T, Choncheewa C
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakorn Pathom 73000, Thailand.
Indian J Pharm Sci. 2015 Jan-Feb;77(1):62-74. doi: 10.4103/0250-474x.151606.
The objective of this investigation was to prepare the shellac wax matrix tablets by fusion and molding technique incorporated with Lutrol in different ratios to modify the hydrophobicity of matrix tablet. The matrix tablets with single drug were loaded either with propranolol hydrochloride or hydrochlorothiazide as hydrophilic and hydrophobic model drugs, and a dual drug formula was also prepared. The single and dual drug release patterns were studied in a dissolution apparatus using distilled water as medium. Propranolol hydrochloride released from matrix was easier than hydrochlorothiazide. Drug release from shellac wax matrix could be enhanced by incorporation of Lutrol. However retardation of drug release from some matrix tablets was evident for the systems that could form dispersion in the dissolution medium. The gel network from high content of Lutrol was hexagonal which was a dense and more compact structure than the other structures found when low amounts of Lutrol were present in the formula. Therefore, the formulae with high content of Lutrol could prolong drug release more efficiently than those containing low content of Lutrol. Hence shellac wax matrix could modulate the drug release with the addition of Lutrol. Sustainable dual drug release was also obtained from these developed matrix tablets. Thus shellac wax-Lutrol component could be used as a potential matrix tablet prepared with fusion and molding technique with excellent controlled drug release.
本研究的目的是通过融合和成型技术制备虫胶蜡基质片，其中加入不同比例的聚氧乙烯蓖麻油以改变基质片的疏水性。单药基质片分别载入盐酸普萘洛尔或氢氯噻嗪作为亲水和疏水模型药物，并制备了双药配方。在以蒸馏水为介质的溶出装置中研究了单药和双药的释放模式。从基质中释放的盐酸普萘洛尔比氢氯噻嗪更容易。加入聚氧乙烯蓖麻油可增强虫胶蜡基质中药物的释放。然而，对于那些能在溶出介质中形成分散体的体系，一些基质片的药物释放明显延迟。高含量聚氧乙烯蓖麻油形成的凝胶网络为六边形，与配方中聚氧乙烯蓖麻油含量低时发现的其他结构相比，它是一种致密且更紧凑的结构。因此，高含量聚氧乙烯蓖麻油的配方比低含量聚氧乙烯蓖麻油的配方能更有效地延长药物释放。因此，虫胶蜡基质可通过添加聚氧乙烯蓖麻油来调节药物释放。从这些开发的基质片中还获得了可持续的双药释放。因此，虫胶蜡 - 聚氧乙烯蓖麻油组分可作为一种潜在的基质片，采用融合和成型技术制备，具有出色的控释性能。
