Ramazanzadeh Rashid, Roshani Daem, Shakib Pegah, Rouhi Samaneh
Department of Microbiology, Cellular and Molecular Research Center, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Department of Epidemiology and Biostatistics, Medical School, Kurdistan University of Medical Sciences, Sanandaj, Iran ; Kurdistan Research Center for Social Determinants of Health, Medical School, Kurdistan University of Medical Sciences, Sanandaj, Iran.
J Res Med Sci. 2015 Jan;20(1):78-88.
Transmission of Mycobacterium tuberculosis (M. tuberculosis) can occur in different ways. Furthermore, drug resistant in M. tuberculosis family is a major problem that creates obstacles in treatment and control of tuberculosis (TB) in the world. One of the most prevalent families of M. tuberculosis is Haarlem, and it is associated with drug resistant. Our objectives of this study were to determine the prevalence and occurrence rate of M. tuberculosis Haarlem family multi-drug resistant (MDR) in the worldwide using meta-analysis based on a systematic review that performed on published articles.
Data sources of this study were 78 original articles (2002-2012) that were published in the literatures in several databases including PubMed, Science Direct, Google Scholar, Biological abstracts, ISI web of knowledge and IranMedex. The articles were systematically reviewed for prevalence and rate of MDR. Data were analyzed using meta-analysis and random effects models with the software package Meta R, Version 2.13 (P < 0.10).
Final analysis included 28601 persons in 78 articles. The highest and lowest occurrence rate of Haarlem family in M. tuberculosis was in Hungary in 2006 (66.20%) with negative MDR-TB and in China in 2010 (0.8%), respectively. From 2002 to 2012, the lowest rate of prevalence was in 2010, and the highest prevalence rate was in 2012. Also 1.076% were positive for MDR and 9.22% were negative (confidence interval: 95%).0020.
Many articles and studies are performed in this field globally, and we only chose some of them. Further studies are needed to be done in this field. Our study showed that M. tuberculosis Haarlem family is prevalent in European countries. According to the presence of MDR that was seen in our results, effective control programs are needed to control the spread of drug-resistant strains, especially Haarlem family.
结核分枝杆菌（M. tuberculosis）的传播方式多种多样。此外，结核分枝杆菌家族中的耐药性是一个重大问题，给全球结核病（TB）的治疗和控制带来了障碍。哈勒姆家族是最常见的结核分枝杆菌家族之一，且与耐药性相关。本研究的目的是通过对已发表文章进行系统评价，采用荟萃分析来确定全球范围内结核分枝杆菌哈勒姆家族多重耐药（MDR）的患病率和发生率。
本研究的数据来源为78篇原创文章（2002 - 2012年），这些文章发表在多个数据库的文献中，包括PubMed、Science Direct、谷歌学术、生物学文摘、ISI知识网络和IranMedex。对这些文章进行系统评价，以获取MDR的患病率和发生率。使用Meta R软件包2.13版（P < 0.10）的荟萃分析和随机效应模型对数据进行分析。
最终分析纳入了78篇文章中的28601人。结核分枝杆菌中哈勒姆家族的最高和最低发生率分别为2006年匈牙利的66.20%（MDR - TB阴性）和2010年中国的0.8%。2002年至2012年期间，患病率最低的是2010年，最高患病率是2012年。此外，MDR阳性率为1.076%，阴性率为9.22%（置信区间：95%）。0020。
全球在该领域开展了许多文章和研究，我们仅选取了其中一部分。该领域还需要进一步开展研究。我们的研究表明，结核分枝杆菌哈勒姆家族在欧洲国家较为普遍。根据我们研究结果中发现的MDR情况，需要有效的控制项目来控制耐药菌株的传播，尤其是哈勒姆家族。
