Navarro-Betancourt José R, Hernández Salomón
Molecular Biology Department, School of Medicine, Universidad Panamericana, Mexico.
Molecular Biology Department, School of Medicine, Universidad Panamericana, Mexico.
Med Hypotheses. 2015 May;84(5):511-5. doi: 10.1016/j.mehy.2015.02.011. Epub 2015 Mar 2.
The most efficient cells for cardiac regeneration are myocardium-resident cardiac stem cells. However, the limited availability of these cells restricts their utility for cardiac cellular therapy. Mesenchymal stem cells can differentiate into a wide variety of tissues, but it is not simple to accurately direct cell differentiation into a specific lineage, such as cardiac tissue; this renders a low efficiency for cardiac regeneration therapy. Given the heterogeneity of mesenchymal stem cells, it may be possible to find specific stem cell subpopulations with a definite differentiation capacity toward cardiac lineage. A parameter to assess cardiac differentiation specificity could be surface marker expression; a population with an immunophenotype similar to cardiac stem cells may have a superior therapeutic value than unsorted mesenchymal stem cells. We hypothesize the existence of a cell line that combines the expression of cardiac stem cell surface markers with those of mesenchymal stem cells, a suitable name for this population is cardiomesenchymal stem cells (CMSC); such cells would be ideal for cardiac regeneration.
用于心脏再生的最有效细胞是心肌驻留心脏干细胞。然而，这些细胞的可用性有限，限制了它们在心脏细胞治疗中的应用。间充质干细胞可以分化为多种组织，但要准确地将细胞分化引导至特定谱系，如心脏组织，并非易事；这使得心脏再生治疗的效率较低。鉴于间充质干细胞的异质性，有可能找到对心脏谱系具有明确分化能力的特定干细胞亚群。评估心脏分化特异性的一个参数可能是表面标志物表达；具有与心脏干细胞相似免疫表型的细胞群可能比未分选的间充质干细胞具有更高的治疗价值。我们推测存在一种结合了心脏干细胞表面标志物与间充质干细胞表面标志物表达的细胞系，这个细胞群的合适名称是心脏间充质干细胞（CMSC）；这类细胞将是心脏再生的理想选择。
