Mosadegh Bobak, Xiong Guanglei, Dunham Simon, Min James K
Dalio Institute of Cardiovascular Imaging, Department of Radiology, Weill Cornell Medical College, New York, NY 10021, USA.
Biomed Mater. 2015 Mar 16;10(3):034002. doi: 10.1088/1748-6041/10/3/034002.
3D printing is a technology that allows the fabrication of structures with arbitrary geometries and heterogeneous material properties. The application of this technology to biological structures that match the complexity of native tissue is of great interest to researchers. This mini-review highlights the current progress of 3D printing for fabricating artificial tissues of the cardiovascular system, specifically the myocardium, heart valves, and coronary arteries. In addition, how 3D printed sensors and actuators can play a role in tissue engineering is discussed. To date, all the work with building 3D cardiac tissues have been proof-of-principle demonstrations, and in most cases, yielded products less effective than other traditional tissue engineering strategies. However, this technology is in its infancy and therefore there is much promise that through collaboration between biologists, engineers and material scientists, 3D bioprinting can make a significant impact on the field of cardiovascular tissue engineering.
3D打印是一种能够制造具有任意几何形状和异质材料特性结构的技术。该技术应用于与天然组织复杂性相匹配的生物结构，引起了研究人员的极大兴趣。本综述重点介绍了3D打印在制造心血管系统人工组织，特别是心肌、心脏瓣膜和冠状动脉方面的当前进展。此外，还讨论了3D打印传感器和致动器如何在组织工程中发挥作用。迄今为止，所有构建3D心脏组织的工作都只是原理验证演示，而且在大多数情况下，所生产的产品比其他传统组织工程策略的效果要差。然而，这项技术尚处于起步阶段，因此，通过生物学家、工程师和材料科学家之间的合作，3D生物打印很有希望在心血管组织工程领域产生重大影响。
