Miętus Magdalena, Marecka Maria, Gołofit Tomasz, Gadomska-Gajadhur Agnieszka
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, Warsaw, 00-664, Poland.
Sci Rep. 2025 Jul 1;15(1):21052. doi: 10.1038/s41598-025-07356-0.
Artificial tissues and organs can be obtained through a modern material processing method - 3D printing. In this method, 3D printing inks are used. Those are most commonly made of polyacrylates which show several undesirable characteristics. Their monomers are petroleum-based compounds that exhibit toxicity, and the final 3D printing ink is often characterized by inadequate viscosity, which hinders printing. Here, we show the potential 3D printing ink synthesis - fully biobased poly(tetramethylene itaconate). It was synthesized from itaconic acid and 1,4-butanediol with the addition of different catalysts. The primary objective was to produce a green product suitable as a bio-ink for bioprinting without toxic additives. We have recognized the main reasons for the undesired reactions during the synthesis of poly(tetramethylene itaconate). Our results demonstrate how the selected catalyst's type and content, temperature, and reaction time play a significant role in finding the optimum synthesis conditions. We anticipate our essay as a starting point for more sophisticated research - polymer 3D printing and cellular research.
人工组织和器官可以通过一种现代材料加工方法——3D打印来获得。在这种方法中，使用3D打印墨水。这些墨水最常见的是由聚丙烯酸酯制成，而聚丙烯酸酯具有一些不良特性。它们的单体是石油基化合物，具有毒性，并且最终的3D打印墨水通常具有粘度不足的特点，这会阻碍打印。在此，我们展示了潜在的3D打印墨水合成——完全生物基的聚（衣康酸丁二醇酯）。它是由衣康酸和1,4 - 丁二醇在添加不同催化剂的情况下合成的。主要目标是生产一种绿色产品，适合作为无有毒添加剂的生物打印生物墨水。我们已经认识到聚（衣康酸丁二醇酯）合成过程中不期望反应的主要原因。我们的结果表明，所选催化剂的类型和含量、温度以及反应时间在寻找最佳合成条件方面起着重要作用。我们期望我们的文章成为更深入研究——聚合物3D打印和细胞研究的起点。
