Lee Hong-Hee, Kim Seong Taek, Lee Kee-Joon, Baik Hyoung-Seon
Departments of *Orthodontics, and †Orofacial Pain and Oral Medicine, School of Dentistry, Yonsei University, Seoul, Korea; ‡Department of Orthodontics, Institute of Craniofacial Deformity, School of Dentistry, Yonsei University, Seoul, Korea.
Dermatol Surg. 2015 Apr;41(4):439-44. doi: 10.1097/DSS.0000000000000291.
Botulinum toxin type A (BoNT-A) is widely used to improve the lower facial contour.
To determine the difference in the changes in the lower facial contour achieved with 1 and 2 sessions of BoNT-A injections using 3-dimensional (3D) laser scanning.
Twenty volunteers were randomly divided into 2 groups. Group I (n = 10) received a single injection, whereas Group II (n = 10) received 2 sessions of injections, the second being administered 4 months after the first. Each injection comprised of 25 U of BoNT-A and was administered to the masseter muscle bilaterally. Evaluation of the effect of BoNT-A injection was performed using 3D laser scan images obtained before the injection and 6 months thereafter in Group I, and before the first injection and 6 months thereafter in the Group II.
The mean changes in the volume and thickness in Group I were -1,186 mm and -1.52 mm, respectively; the corresponding changes were -4,072 mm and -3.84 mm in Group II. The reductions were significantly greater in Group II than in Group I.
The administration of a second BoNT-A injection is effective for better aesthetic results for the lower facial contour.
A型肉毒毒素（BoNT-A）被广泛用于改善下面部轮廓。
使用三维（3D）激光扫描确定1次和2次BoNT-A注射所实现的下面部轮廓变化的差异。
20名志愿者被随机分为2组。第一组（n = 10）接受单次注射，而第二组（n = 10）接受2次注射，第二次注射在第一次注射后4个月进行。每次注射包含25 U的BoNT-A，双侧咬肌均接受注射。使用注射前及I组注射后6个月、II组第一次注射前及第一次注射后6个月获得的3D激光扫描图像对BoNT-A注射效果进行评估。
I组的体积和厚度平均变化分别为-1,186 mm和-1.52 mm；II组相应的变化分别为-4,072 mm和-3.84 mm。II组的减少量显著大于I组。
第二次注射BoNT-A对于改善下面部轮廓的美学效果有效。
