Lee Hwa-Jin, Kim Sung-Jin, Lee Kee-Joon, Yu Hyung-Seog, Baik Hyoung-Seon
Department of Orthodontics, School of Dentistry, Yonsei University, Seoul, Korea.
Institute of Craniofacial Deformity, School of Dentistry, Yonsei University, Seoul, Korea.
Korean J Orthod. 2017 Jul;47(4):222-228. doi: 10.4041/kjod.2017.47.4.222. Epub 2017 May 26.
To evaluate soft- and hard-tissue changes in the mandibular angle area after the administration of botulinum toxin type A (BoNT-A) injection to patients with masseteric hypertrophy by using three-dimensional cone-beam computed tomography (3D-CBCT).
Twenty volunteers were randomly divided into two groups of 10 patients. Patients in group I received a single BoNT-A injection in both masseter muscles, while those in group II received two BoNT-A injections in each masseter muscle, with the second injection being administered 4 months after the first one. In both groups, 3D-CBCT was performed before the first injection and 6 months after the first injection.
Masseter muscle thicknesses and cross-sectional areas were significantly reduced in both groups, but the reductions were significantly more substantial in group II than in group I. The intergonial width of the mandibular angle area did not change significantly in either group. However, the bone volume of the mandibular gonial angle area was more significantly reduced in group II than in group I.
The repeated administration of BoNT-A injections may induce bone volume changes in the mandibular angle area.
通过三维锥形束计算机断层扫描（3D-CBCT）评估A型肉毒毒素（BoNT-A）注射治疗咬肌肥大患者后下颌角区域的软组织和硬组织变化。
20名志愿者随机分为两组，每组10名患者。第一组患者双侧咬肌各注射一次BoNT-A，而第二组患者双侧咬肌各注射两次BoNT-A，第二次注射在第一次注射后4个月进行。两组患者均在第一次注射前和第一次注射后6个月进行3D-CBCT检查。
两组咬肌厚度和横截面积均显著减小，但第二组的减小幅度明显大于第一组。两组下颌角区域的下颌角间宽度均无明显变化。然而，第二组下颌角区域的骨体积减少比第一组更显著。
重复注射BoNT-A可能会引起下颌角区域的骨体积变化。
