Suepaul S M, Carrington C V, Campbell M, Borde G, Adesiyun A A
School of Veterinary Medicine, Faculty of Medical Sciences, The University of the West Indies, Trinidad and Tobago.
School of Medicine, Faculty of Medical Sciences, The University of the West Indies, Trinidad and Tobago.
Trop Biomed. 2014 Dec;31(4):853-61.
Stray dogs (n=207), suspected canine cases of leptospirosis (n=50) and rats (n=200) from the Caribbean island of Trinidad were subjected to the Microscopic Agglutination Test (MAT) for leptospirosis. The seroprevalence in stray dogs was 15.5% (n=32), the predominant serogroup was Icterohaemorrhagiae (14.5%; n=30) with agglutinations to serovars Copenhageni at 5.8%, Icterohaemorrhagiae at 4.8%, Mankarso at 3.9%. The seroprevalence among suspected canine cases was 72% (n=36) with Icterohaemorrhagiae again being the predominant serogroup at 60% inclusive of serovars: Copenhageni, 44%; Mankarso, 14%; and Icterohaemorrhagiae 2%. A seroprevalence of 16.5% was determined in rats, all agglutinations were to the Icterohaemorrhagiae serogroup (inclusive of serovars Copenhageni, 9.5%; Icterohaemorrhagiae, 5.5%; and Mankarso, 1.5%). Overall serovar Copenhageni was the most common serovar as 11.6% of all the animal species tested by the MAT were positive and may be an important zoonotic serovar in Trinidad. The titres of infecting serovars of Leptospira in suspected canine cases of leptospirosis were considerably higher than that found in stray dogs and in rats where the lowest titres were found. Age and sex were not significant risk factors except in the case of rats where age was significant, indicating that juvenile rats were at a significantly higher risk. There was no definite pattern of the distribution of positive animals or the serovars when using the MAT. Data obtained in the current study indicate that dogs and rats in Trinidad have the potential to be sources of leptospiral infections for humans. This potential has public health implications making it imperative to control rat and stray dog populations in the island to reduce the risk of human leptospirosis.
对来自加勒比海岛国特立尼达的207只流浪狗、50例疑似钩端螺旋体病犬病例以及200只老鼠进行了钩端螺旋体病的显微镜凝集试验（MAT）。流浪狗的血清阳性率为15.5%（n = 32），主要血清群为出血性黄疸型（14.5%；n = 30），其中哥本哈根血清型的凝集率为5.8%，出血性黄疸型为4.8%，曼卡索型为3.9%。疑似犬病例中的血清阳性率为72%（n = 36），出血性黄疸型同样是主要血清群，占60%，包括哥本哈根血清型，44%；曼卡索型，14%；出血性黄疸型，2%。在老鼠中测定的血清阳性率为16.5%，所有凝集均针对出血性黄疸型血清群（包括哥本哈根血清型，9.5%；出血性黄疸型，5.5%；曼卡索型，1.5%）。总体而言，哥本哈根血清型是最常见的血清型，因为通过MAT检测的所有动物物种中有11.6%呈阳性，它可能是特立尼达一种重要的人畜共患病血清型。钩端螺旋体病疑似犬病例中感染血清型的滴度明显高于流浪狗和老鼠中发现的滴度，老鼠中的滴度最低。年龄和性别不是显著的风险因素，但在老鼠中年龄是显著因素，表明幼年老鼠的风险显著更高。使用MAT时，阳性动物或血清型的分布没有明确模式。本研究获得的数据表明，特立尼达的狗和老鼠有可能成为人类钩端螺旋体感染的来源。这种可能性对公共卫生有影响，因此必须控制该岛的老鼠和流浪狗数量，以降低人类感染钩端螺旋体病的风险。
Zotero 插件