自身免疫性疾病的表观基因组学
Epigenomics of autoimmune diseases.
作者信息
Gupta Bhawna, Hawkins R David
机构信息
School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.
1] Division of Medical Genetics-Department of Medicine, Department of Genome Sciences, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, USA [2] Turku Centre for Biotechnology, Turku, Finland.
出版信息
Immunol Cell Biol. 2015 Mar;93(3):271-6. doi: 10.1038/icb.2015.18.
Autoimmune diseases are complex disorders of largely unknown etiology. Genetic studies have identified a limited number of causal genes from a marginal number of individuals, and demonstrated a high degree of discordance in monozygotic twins. Studies have begun to reveal epigenetic contributions to these diseases, primarily through the study of DNA methylation, but chromatin and non-coding RNA changes are also emerging. Moving forward an integrative analysis of genomic, transcriptomic and epigenomic data, with the latter two coming from specific cell types, will provide an understanding that has been missed from genetics alone. We provide an overview of the current state of the field and vision for deriving the epigenomics of autoimmunity.
自身免疫性疾病是病因大多不明的复杂病症。基因研究已从数量有限的个体中鉴定出了少数致病基因，并在同卵双胞胎中发现了高度的不一致性。相关研究已开始揭示表观遗传学对这些疾病的影响，主要是通过对DNA甲基化的研究，但染色质和非编码RNA的变化也逐渐显现出来。展望未来，对基因组、转录组和表观基因组数据进行综合分析（后两者数据来自特定细胞类型），将带来仅靠遗传学无法获得的认识。我们概述了该领域的当前状况以及推导自身免疫表观基因组学的前景。
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