葡萄牙产碳青霉烯酶肠杆菌科细菌调查中KPC-3的优势地位。
Predominance of KPC-3 in a survey for carbapenemase-producing Enterobacteriaceae in Portugal.
作者信息
Manageiro Vera, Ferreira Eugénia, Almeida Joana, Barbosa Stephanie, Simões Constança, Bonomo Robert A, Caniça Manuela
机构信息
National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections (NRL-AMR-HAI), Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal CECA-ICETA, Centro de Estudos de Ciência Animal, Universidade do Porto, Porto, Portugal.
National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections (NRL-AMR-HAI), Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal.
出版信息
Antimicrob Agents Chemother. 2015;59(6):3588-92. doi: 10.1128/AAC.05065-14. Epub 2015 Mar 16.
Abstract
Among the 2,105 Enterobacteriaceae tested in a survey done in Portugal, 165 were nonsusceptible to carbapenems, from which 35 (26 Klebsiella pneumoniae, 3 Escherichia coli, 2 Enterobacter aerogenes, and 3 Enterobacter cloacae isolates and 1 Klebsiella oxytoca isolate) were confirmed to be carbapenemase producers by the presence of 30 Tn4401d-blaKPC-3, 4 intI3-blaGES-5, and one intI1-blaVIM-2 gene, alone or in combination with other bla genes. The dissemination of blaKPC-3 gene carried by an IncF plasmid suggests lateral gene transfer as a major mechanism of dissemination.
摘要
在葡萄牙进行的一项调查中检测的2105株肠杆菌科细菌中，有165株对碳青霉烯类不敏感，其中35株（26株肺炎克雷伯菌、3株大肠埃希菌、2株产气肠杆菌、3株阴沟肠杆菌分离株和1株产酸克雷伯菌分离株）通过单独或与其他bla基因组合存在30个Tn4401d-blaKPC-3、4个intI3-blaGES-5和1个intI1-blaVIM-2基因而被确认为碳青霉烯酶产生菌。由IncF质粒携带的blaKPC-3基因的传播表明横向基因转移是传播的主要机制。
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