Ganzer U
Laryngol Rhinol Otol (Stuttg). 1985 Jan;64(1):21-4.
Despite all progress in the therapy of malignant head and neck tumours, about 50% of our patients succumb to their carcinoma or its metastases. For these patients, palliative measures which, at least temporarily, will improve their general condition and the function of respiration as well as food intake, are missing. One, and at the presents perhaps the best, palliative therapy seems to be the so-called synchronization therapy. This therapeutic concept will be discussed here in consideration of experimental basic research and the clinical results. Radiation treatment after partial synchronization of the tumour cells leads with acceptable side effects in more than a half of all cases to a satisfactory or good general condition and food intake, and in nearly one-third of the patients to a distinct prolongation of their life under tolerable circumstances. Additionally, the abatement of tumorous pain and the possibility of ingestion give rise to a clear improvement of the psychic situation of the patient.
尽管在恶性头颈部肿瘤的治疗方面取得了所有进展，但我们约50%的患者仍死于其癌症或转移瘤。对于这些患者来说，目前至少能暂时改善其一般状况、呼吸功能以及食物摄入的姑息治疗措施尚不存在。一种，且目前可能是最佳的姑息治疗方法似乎是所谓的同步化治疗。在此，将结合实验基础研究和临床结果对这一治疗理念进行讨论。在肿瘤细胞部分同步化后进行放射治疗，在超过一半的病例中会产生可接受的副作用，使患者的一般状况和食物摄入达到满意或良好水平，并且在近三分之一的患者中，在可耐受的情况下能显著延长其生命。此外，肿瘤疼痛的减轻以及进食的可能性使患者的心理状况明显改善。
