Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, 5 University Street, University College London, London WC1E 6JJ, UK.
Immunity. 2015 Mar 17;42(3):397-9. doi: 10.1016/j.immuni.2015.02.016.
How the immune system is negatively affected by sepsis is not fully understood. In this issue of Immunity, Shalova et al. (2015) show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties.
目前尚未完全了解脓毒症如何对免疫系统造成负面影响。在本期《免疫》杂志中，Shalova 等人（2015）表明，在人类脓毒症中，单核细胞上调缺氧诱导因子-α（HIF1-α）的活性，并获得免疫抑制表型，同时保留抗细菌和伤口愈合的特性。
