癌症患者白细胞和肿瘤DNA中人类Ha-ras基因座的独特等位基因限制性片段。
Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients.
作者信息
Krontiris T G, DiMartino N A, Colb M, Parkinson D R
出版信息
Nature. 1985;313(6001):369-74. doi: 10.1038/313369a0.
DOI:10.1038/313369a0
PMID:2578622
Abstract
White blood cell DNA from cancer patients and DNA from tumours and tumour-derived cell lines frequently demonstrated allelic restriction fragments of the Harvey ras oncogene locus not found in the unaffected population. The presence of such unusual alleles may be linked to susceptibility to cancer.
摘要
癌症患者的白细胞DNA以及肿瘤和肿瘤衍生细胞系的DNA，经常显示出未在未受影响人群中发现的哈维鼠肉瘤病毒癌基因位点的等位基因限制性片段。这些异常等位基因的存在可能与癌症易感性有关。
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