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癌症患者白细胞和肿瘤DNA中人类Ha-ras基因座的独特等位基因限制性片段。

Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients.

作者信息

Krontiris T G, DiMartino N A, Colb M, Parkinson D R

出版信息

Nature. 1985;313(6001):369-74. doi: 10.1038/313369a0.

DOI:10.1038/313369a0
PMID:2578622
Abstract

White blood cell DNA from cancer patients and DNA from tumours and tumour-derived cell lines frequently demonstrated allelic restriction fragments of the Harvey ras oncogene locus not found in the unaffected population. The presence of such unusual alleles may be linked to susceptibility to cancer.

摘要

癌症患者的白细胞DNA以及肿瘤和肿瘤衍生细胞系的DNA，经常显示出未在未受影响人群中发现的哈维鼠肉瘤病毒癌基因位点的等位基因限制性片段。这些异常等位基因的存在可能与癌症易感性有关。

相似文献

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Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients.癌症患者白细胞和肿瘤DNA中人类Ha-ras基因座的独特等位基因限制性片段。
Nature. 1985;313(6001):369-74. doi: 10.1038/313369a0.
2
Lack of correlation between rare Ha-ras alleles and urothelial cancer in Japan.日本罕见的Ha-ras等位基因与尿路上皮癌之间缺乏相关性。
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A sensitive non-radioactive PCR-RFLP analysis for detecting point mutations at 12th codon of oncogene c-Ha-ras in DNAs of gastric cancer.一种用于检测胃癌DNA中癌基因c-Ha-ras第12密码子点突变的灵敏非放射性聚合酶链反应-限制性片段长度多态性分析。
Nucleic Acids Res. 1988 Jul 11;16(13):6231. doi: 10.1093/nar/16.13.6231.
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[Study on Ha-ras RFLPs in gastric carcinoma and normal tissue DNAs of Chinese individuals].[中国人胃癌组织及正常组织DNA中Ha-ras限制性片段长度多态性研究]
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Comparison between the allelic frequency distribution of the Ha-ras 1 locus in normal individuals and patients with lymphoma, breast, and ovarian cancer.
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Presence of an allelic EcoRI restriction fragment of the c-mos locus in leukocyte and tumor cell DNAs of breast cancer patients.
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Ha-ras restriction fragment length polymorphisms in colorectal cancer.结直肠癌中的Ha-ras限制性片段长度多态性
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Ha-ras hypervariable alleles in myelodysplasia.骨髓增生异常综合征中的Ha-ras高变等位基因
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Hypomethylation of ras oncogenes in primary human cancers.
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Loss of allelic heterozygosity at the harvey ras locus in human oral carcinomas.人类口腔癌中哈维鼠肉瘤病毒癌基因同源物（harvey ras）位点的等位基因杂合性缺失
J Cancer Res Clin Oncol. 1991;117(5):484-8. doi: 10.1007/BF01612771.

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