Grabska-Liberek Iwona, Skonieczna Katarzyna, Olesińska Marzena, Terelak-Borys Barbara, Kocięcki Jarosław, Sikora Mariusz, Jamrozy-Witkowska Agnieszka, Tesla Piotr, Czarnocka Barbara
Department of Ophthalmology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Department of Connective Tissue Diseases, Institute of Rheumatology, Warsaw, Poland.
Med Sci Monit. 2015 Mar 19;21:828-32. doi: 10.12659/MSM.893349.
Although elevated intraocular pressure is a major risk factor for the development of glaucoma, there is increasing evidence that the immune system may be involved in the development of normal-tension glaucoma (NTG). The aim of this study was to determine if NTG is associated with elevated levels of antibodies against human heat shock protein (HSP) 60.
The study was conducted in 139 subjects (35 subjects with NTG [Group 1], 34 subjects with primary open-angle glaucoma /POAG/ [Group 2], 24 subjects with autoimmune rheumatic diseases [Group 3], and 36 healthy controls [Group 4]). All subjects had complete ophthalmologic examination (visual acuity, slit-lamp examination, tonometry, gonioscopy; visual-field examination, and optical coherence tomography /OCT/ of the optic nerve head and the macula). Blood samples were collected for the measurements of serum levels of antibodies against human HSP60.
The subjects with rheumatic diseases had the highest median serum level of antibodies against HSP60 - 20.49 ng/mL. The values in the subjects with NTG, POAG, and in controls were 18.79 ng/mL, 18.61 ng/mL and 17.61 ng/mL, respectively (p=0.96).
This study does not confirm the hypothesis that normal-tension glaucoma is associated with elevated blood levels of antibodies against human heat shock protein (HSP) 60.
虽然眼压升高是青光眼发病的主要危险因素，但越来越多的证据表明免疫系统可能参与正常眼压性青光眼（NTG）的发病过程。本研究的目的是确定NTG是否与抗人热休克蛋白（HSP）60抗体水平升高有关。
该研究纳入了139名受试者（35名NTG患者[第1组]，34名原发性开角型青光眼/POAG/患者[第2组]，24名自身免疫性风湿性疾病患者[第3组]，以及36名健康对照者[第4组]）。所有受试者均接受了全面的眼科检查（视力、裂隙灯检查、眼压测量、前房角镜检查、视野检查以及视神经乳头和黄斑的光学相干断层扫描/OCT/）。采集血样以测量血清中抗人HSP60抗体水平。
风湿性疾病患者抗HSP60抗体的血清中位数水平最高——20.49 ng/mL。NTG患者、POAG患者及对照组的该值分别为18.79 ng/mL、18.61 ng/mL和17.61 ng/mL（p = 0.96）。
本研究未证实正常眼压性青光眼与抗人热休克蛋白（HSP）60抗体血水平升高相关这一假说。
