Watkins C A, Burkhart L R, Rannels D E
Am J Physiol. 1985 Feb;248(2 Pt 1):E162-9. doi: 10.1152/ajpendo.1985.248.2.E162.
The rapidity with which lung growth is initiated and completed after pneumonectomy was examined in young rats (4 wk of age; 82 g). After left pneumonectomy, the remaining lobes of the right lung grew to equal the weight of both lungs of control animals by day 7 and within 14 days increased from 366 to 968 mg. The tissue concentrations of RNA, DNA phosphate, collagen, and noncollagen proteins did not increase during the growth response. In contrast, total amounts of these constituents increased significantly in the remaining lung of pneumonectomized animals during the 1st postoperative wk and approached levels found in both lungs of sham-operated and unoperated controls by the end of the 2nd wk after pneumonectomy. Although cell size increased in control lungs during the experimental period, there was little evidence of additional cellular hypertrophy associated with compensatory lung growth. The character of the response to pneumonectomy in these rats was similar to that observed previously in older animals (320 g). Thus in spite of the higher basal rate of lung growth in the younger rats, the pattern and rapidity of compensation after pneumonectomy was similar in both age groups.
在幼鼠（4周龄；82克）中研究了肺切除术后肺生长启动和完成的速度。左肺切除术后，右肺剩余叶在第7天时生长到与对照动物双肺重量相等，并在14天内从366毫克增加到968毫克。在生长反应过程中，RNA、DNA磷酸盐、胶原蛋白和非胶原蛋白的组织浓度没有增加。相反，在术后第1周，这些成分的总量在肺切除动物的剩余肺中显著增加，到肺切除术后第2周结束时接近假手术和未手术对照动物双肺中的水平。尽管在实验期间对照肺中的细胞大小增加，但几乎没有证据表明与代偿性肺生长相关的额外细胞肥大。这些大鼠对肺切除术的反应特征与先前在老年动物（320克）中观察到的相似。因此，尽管幼鼠的肺生长基础速率较高，但两个年龄组肺切除术后的代偿模式和速度相似。
