Huang Xiaoyan, Dugo Matteo, Callari Maurizio, Sandri Marco, De Cecco Loris, Valeri Barbara, Carcangiu Maria Luisa, Xue Jingyan, Bi Rui, Veneroni Silvia, Daidone Maria Grazia, Ménard Sylvie, Tagliabue Elda, Shao Zhimin, Wu Jiong, Orlandi Rosaria
Department of Breast Surgery, Fudan University Shanghai Cancer Center and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Functional Genomics and Bioinformatics, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Cancer Med. 2015 Jul;4(7):1016-30. doi: 10.1002/cam4.442. Epub 2015 Mar 18.
The recent dramatic increase in breast cancer incidence across China with progressive urbanization and economic development has signaled the urgent need for molecular and clinical detailing of breast cancer in the Chinese population. Our analyses of a unique transethnic collection of breast cancer frozen specimens from Shanghai Fudan Cancer Center (Chinese Han) profiled simultaneously with an analogous Caucasian Italian series revealed consistent transcriptomic data lacking in batch effects. The prevalence of Luminal A subtype was significantly lower in Chinese series, impacting the overall prevalence of estrogen receptor (ER)-positive disease in a large cohort of Chinese/Caucasian patients. Unsupervised and supervised comparison of gene and microRNA (miRNA) profiles of Chinese and Caucasian samples revealed extensive similarity in the comprehensive taxonomy of transcriptional elements regulating breast cancer biology. Partition of gene expression data using gene lists relevant to breast cancer as "intrinsic" and "extracellular matrix" genes identified Chinese and Caucasian subgroups with equivalent global gene and miRNA profiles. These findings indicate that in the Chinese and Caucasian groups, breast neoplasia and the surrounding stromal characteristics undergo the same differentiation and molecular processes. Transcriptional similarity across transethnic cohorts may simplify translational medicine approaches and clinical management of breast cancer patients worldwide.
随着中国城市化进程的推进和经济的发展，近期乳腺癌发病率急剧上升，这表明迫切需要对中国人群的乳腺癌进行分子和临床详细研究。我们对上海复旦大学附属肿瘤医院（中国汉族）独特的跨种族乳腺癌冷冻标本进行分析，并与类似的意大利白种人系列标本同时进行分析，结果显示转录组数据一致，不存在批次效应。中国系列中Luminal A亚型的患病率显著较低，这影响了一大群中国/白种人患者中雌激素受体（ER）阳性疾病的总体患病率。对中国和白种人样本的基因和微小RNA（miRNA）谱进行无监督和有监督比较，发现在调节乳腺癌生物学的转录元件综合分类中存在广泛相似性。使用与乳腺癌相关的基因列表作为“内在”和“细胞外基质”基因对基因表达数据进行划分，确定了具有等效全局基因和miRNA谱的中国和白种人亚组。这些发现表明，在中国和白种人群体中，乳腺肿瘤及周围基质特征经历相同的分化和分子过程。跨种族队列之间的转录相似性可能会简化全球乳腺癌患者的转化医学方法和临床管理。
