Ha Ngoc-Thuy, Gross Josef Johann, van Dorland Annette, Tetens Jens, Thaller Georg, Schlather Martin, Bruckmaier Rupert, Simianer Henner
Veterinary Physiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland; Animal Breeding and Genetics Group, Department of Animal Sciences, Georg-August-University, Goettingen, Germany.
Veterinary Physiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
PLoS One. 2015 Mar 19;10(3):e0122325. doi: 10.1371/journal.pone.0122325. eCollection 2015.
The metabolic adaptation of dairy cows during the transition period has been studied intensively in the last decades. However, until now, only few studies have paid attention to the genetic aspects of this process. Here, we present the results of a gene-based mapping and pathway analysis with the measurements of three key metabolites, (1) non-esterified fatty acids (NEFA), (2) beta-hydroxybutyrate (BHBA) and (3) glucose, characterizing the metabolic adaptability of dairy cows before and after calving. In contrast to the conventional single-marker approach, we identify 99 significant and biologically sensible genes associated with at least one of the considered phenotypes and thus giving evidence for a genetic basis of the metabolic adaptability. Moreover, our results strongly suggest three pathways involved in the metabolism of steroids and lipids are potential candidates for the adaptive regulation of dairy cows in their early lactation. From our perspective, a closer investigation of our findings will lead to a step forward in understanding the variability in the metabolic adaptability of dairy cows in their early lactation.
在过去几十年里，人们对奶牛围产期的代谢适应性进行了深入研究。然而，到目前为止，只有少数研究关注了这一过程的遗传方面。在此，我们展示了基于基因的图谱绘制和通路分析结果，同时测量了三种关键代谢物：（1）非酯化脂肪酸（NEFA）、（2）β-羟基丁酸（BHBA）和（3）葡萄糖，以表征奶牛产犊前后的代谢适应性。与传统的单标记方法不同，我们鉴定出99个与至少一种所考虑表型相关的显著且具有生物学意义的基因，从而为代谢适应性的遗传基础提供了证据。此外，我们的结果强烈表明，参与类固醇和脂质代谢的三条通路是奶牛早期泌乳适应性调节的潜在候选通路。从我们的角度来看，对我们的发现进行更深入的研究将有助于在理解奶牛早期泌乳代谢适应性变异性方面取得进展。
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