• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.

作者信息

Nasica-Labouze Jessica, Nguyen Phuong H, Sterpone Fabio, Berthoumieu Olivia, Buchete Nicolae-Viorel, Coté Sébastien, De Simone Alfonso, Doig Andrew J, Faller Peter, Garcia Angel, Laio Alessandro, Li Mai Suan, Melchionna Simone, Mousseau Normand, Mu Yuguang, Paravastu Anant, Pasquali Samuela, Rosenman David J, Strodel Birgit, Tarus Bogdan, Viles John H, Zhang Tong, Wang Chunyu, Derreumaux Philippe

机构信息

†Laboratoire de Biochimie Théorique, Institut de Biologie Physico-Chimique (IBPC), UPR9080 CNRS, Université Paris Diderot, Sorbonne Paris Cité, 13 rue Pierre et Marie Curie, 75005 Paris, France.

‡LCC (Laboratoire de Chimie de Coordination), CNRS, Université de Toulouse, Université Paul Sabatier (UPS), Institut National Polytechnique de Toulouse (INPT), 205 route de Narbonne, BP 44099, Toulouse F-31077 Cedex 4, France.

出版信息

Chem Rev. 2015 May 13;115(9):3518-63. doi: 10.1021/cr500638n. Epub 2015 Mar 19.

DOI:10.1021/cr500638n
PMID:25789869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5504919/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/a4c1e720e15c/nihms866047f17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/27180fc47d85/nihms866047f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/151efc729197/nihms866047f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/a66a9c85df39/nihms866047f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/f25453bf2a56/nihms866047f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/f81e6d55f0b9/nihms866047f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/4f100f6ebb74/nihms866047f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/89ddbf1c29dd/nihms866047f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/4cb4c81e9863/nihms866047f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/1368061951ab/nihms866047f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/4bacf449d8af/nihms866047f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/669f0f152053/nihms866047f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/b04dfcb4b9fe/nihms866047f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/d226a81b5dc3/nihms866047f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/8a50407f2d06/nihms866047f14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/ee0cdccab3da/nihms866047f15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/1cd82acb33fe/nihms866047f16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/a4c1e720e15c/nihms866047f17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/27180fc47d85/nihms866047f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/151efc729197/nihms866047f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/a66a9c85df39/nihms866047f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/f25453bf2a56/nihms866047f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/f81e6d55f0b9/nihms866047f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/4f100f6ebb74/nihms866047f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/89ddbf1c29dd/nihms866047f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/4cb4c81e9863/nihms866047f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/1368061951ab/nihms866047f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/4bacf449d8af/nihms866047f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/669f0f152053/nihms866047f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/b04dfcb4b9fe/nihms866047f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/d226a81b5dc3/nihms866047f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/8a50407f2d06/nihms866047f14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/ee0cdccab3da/nihms866047f15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/1cd82acb33fe/nihms866047f16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a419/5504919/a4c1e720e15c/nihms866047f17.jpg

相似文献

1
Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.淀粉样β蛋白与阿尔茨海默病:计算机模拟对实验研究的补充作用
Chem Rev. 2015 May 13;115(9):3518-63. doi: 10.1021/cr500638n. Epub 2015 Mar 19.
2
The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization.淀粉样β肽:化学家的视角。在阿尔茨海默病及纤维化中的作用。
Chem Rev. 2012 Oct 10;112(10):5147-92. doi: 10.1021/cr3000994. Epub 2012 Jul 19.
3
Amyloid beta/A4 peptide associated with Alzheimer's disease and cerebral amyloid angiopathy.与阿尔茨海默病和脑淀粉样血管病相关的β淀粉样蛋白/A4肽。
Intern Med. 1993 Dec;32(12):923-5. doi: 10.2169/internalmedicine.32.923.
4
Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.用分子模拟深入了解阿尔茨海默病和帕金森病的分子机制:了解与病理学相关的无序蛋白质中人工和病理性错义突变的作用。
Int J Mol Sci. 2018 Jan 24;19(2):336. doi: 10.3390/ijms19020336.
5
Insights into Aβ aggregation: a molecular dynamics perspective.对 Aβ 聚集的深入了解:从分子动力学角度。
Curr Top Med Chem. 2012;12(22):2596-610. doi: 10.2174/1568026611212220012.
6
A beta A4 amyloid precursor protein gene and Alzheimer's disease.β淀粉样前体蛋白基因与阿尔茨海默病。
Eur J Biochem. 1996 Apr 1;237(1):6-15. doi: 10.1111/j.1432-1033.1996.0006n.x.
7
Alzheimer's disease and the amyloid β-protein.阿尔茨海默病与淀粉样β蛋白。
Prog Mol Biol Transl Sci. 2012;107:101-24. doi: 10.1016/B978-0-12-385883-2.00012-6.
8
Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.用于阿尔茨海默病淀粉样斑块分子靶向的 6 肽淀粉样β蛋白衍生噬菌体展示文库的设计与评价:与源自随机噬菌体展示文库的两个环状七肽的比较。
Peptides. 2011 Jun;32(6):1232-43. doi: 10.1016/j.peptides.2011.04.026. Epub 2011 May 6.
9
Therapeutic approaches related to amyloid-beta peptide and Alzheimer's disease.与β-淀粉样蛋白肽和阿尔茨海默病相关的治疗方法。
J Med Chem. 1995 Oct 13;38(21):4141-54. doi: 10.1021/jm00021a001.
10
Biochemistry of Alzheimer's disease amyloid plaques.阿尔茨海默病淀粉样斑块的生物化学
Clin Biochem. 1993 Oct;26(5):339-49. doi: 10.1016/0009-9120(93)90110-r.

引用本文的文献

1
A novel fluorescent probe, triphenylamine rhodamine-3-acetic acid (mRA) for the detection of Amyloid-β aggregates in Alzheimer's disease.一种用于检测阿尔茨海默病中β淀粉样蛋白聚集体的新型荧光探针——三苯胺罗丹明-3-乙酸(mRA)。
Front Neurosci. 2025 Aug 21;19:1653063. doi: 10.3389/fnins.2025.1653063. eCollection 2025.
2
Inhibitory mechanisms of amentoflavone on amyloid-β peptide aggregation revealed by replica exchange molecular dynamics.通过副本交换分子动力学揭示穗花杉双黄酮对淀粉样β肽聚集的抑制机制
Sci Rep. 2025 Jul 8;15(1):24352. doi: 10.1038/s41598-025-10623-9.
3
Ensemble Docking for Intrinsically Disordered Proteins.

本文引用的文献

1
Are coarse-grained models apt to detect protein thermal stability? The case of OPEP force field.粗粒度模型是否易于检测蛋白质的热稳定性?以OPEP力场为例。
J Non Cryst Solids. 2015 Jan 1;407:494-501. doi: 10.1016/j.jnoncrysol.2014.07.005. Epub 2014 Jul 22.
2
Distinct Morphologies for Amyloid Beta Protein Monomer: Aβ1-40, Aβ1-42, and Aβ1-40(D23N).淀粉样β蛋白单体的不同形态:Aβ1-40、Aβ1-42和Aβ1-40(D23N)
J Chem Theory Comput. 2011 Aug 9;7(8):2584-92. doi: 10.1021/ct1006967. Epub 2011 Jun 29.
3
Assessing the Quality of the OPEP Coarse-Grained Force Field.
内在无序蛋白质的集成对接
J Chem Inf Model. 2025 Jul 14;65(13):6847-6860. doi: 10.1021/acs.jcim.5c00370. Epub 2025 Jun 18.
4
Formation of a β-Endorphin Corona Mitigates Alzheimer's Amyloidogenesis.β-内啡肽晕圈的形成减轻阿尔茨海默病的淀粉样蛋白生成。
Small. 2025 Jul;21(26):e2409392. doi: 10.1002/smll.202409392. Epub 2025 May 19.
5
Use of AI-methods over MD simulations in the sampling of conformational ensembles in IDPs.在内在无序蛋白质构象集合采样中,人工智能方法相较于分子动力学模拟的应用。
Front Mol Biosci. 2025 Apr 8;12:1542267. doi: 10.3389/fmolb.2025.1542267. eCollection 2025.
6
Small-Molecule Inhibitors of Amyloid Beta: Insights from Molecular Dynamics-Part A: Endogenous Compounds and Repurposed Drugs.β-淀粉样蛋白的小分子抑制剂:分子动力学的见解 - A部分:内源性化合物和重新利用的药物
Pharmaceuticals (Basel). 2025 Feb 23;18(3):306. doi: 10.3390/ph18030306.
7
Physics-informed machine learning for automatic model reduction in chemical reaction networks.用于化学反应网络自动模型简化的物理信息机器学习
Sci Rep. 2025 Mar 7;15(1):7980. doi: 10.1038/s41598-025-92680-8.
8
Ensemble docking for intrinsically disordered proteins.内在无序蛋白质的集成对接
bioRxiv. 2025 Jan 26:2025.01.23.634614. doi: 10.1101/2025.01.23.634614.
9
Survey of the Aβ-peptide structural diversity: molecular dynamics approaches.Aβ 肽结构多样性研究:分子动力学方法
Biophys Rev. 2024 Nov 20;16(6):701-722. doi: 10.1007/s12551-024-01253-y. eCollection 2024 Dec.
10
Fluid flow and amyloid transport and aggregation in the brain interstitial space.脑间质空间中的流体流动以及淀粉样蛋白的转运与聚集
PNAS Nexus. 2024 Dec 7;4(1):pgae548. doi: 10.1093/pnasnexus/pgae548. eCollection 2025 Jan.
评估 OPEP 粗粒化力场的质量。
J Chem Theory Comput. 2011 Jun 14;7(6):1928-34. doi: 10.1021/ct100646f. Epub 2011 May 19.
4
Improved PEP-FOLD Approach for Peptide and Miniprotein Structure Prediction.用于肽和小蛋白质结构预测的改进型PEP-FOLD方法
J Chem Theory Comput. 2014 Oct 14;10(10):4745-58. doi: 10.1021/ct500592m.
5
Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats.淀粉样蛋白积累是未转基因大鼠散发性阿尔茨海默病样病理中的晚期事件。
Oncotarget. 2015 Jan 30;6(3):1396-413. doi: 10.18632/oncotarget.2751.
6
Modulation of Alzheimer's Aβ protofilament-membrane interactions by lipid headgroups.脂质头部基团对阿尔茨海默病β-淀粉样蛋白原纤维与膜相互作用的调节
ACS Chem Neurosci. 2015 Mar 18;6(3):446-55. doi: 10.1021/cn500277f. Epub 2015 Jan 29.
7
Inhibition of protein aggregation and amyloid formation by small molecules.小分子对蛋白质聚集和淀粉样蛋白形成的抑制作用。
Curr Opin Struct Biol. 2015 Feb;30:50-56. doi: 10.1016/j.sbi.2014.12.004. Epub 2015 Jan 2.
8
Importance of the ion-pair interactions in the OPEP coarse-grained force field: parametrization and validation.离子对相互作用在OPEP粗粒化力场中的重要性:参数化与验证
J Chem Theory Comput. 2013 Oct 8;9(10):4574-4584. doi: 10.1021/ct4003493.
9
Kinetic intermediates in amyloid assembly.淀粉样蛋白组装中的动力学中间体。
J Am Chem Soc. 2014 Oct 29;136(43):15146-9. doi: 10.1021/ja508621b. Epub 2014 Oct 21.
10
Monoclonal antibodies against Aβ42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain.抗Aβ42原纤维的单克隆抗体可在体外和阿尔茨海默病大脑中区分多种聚集状态多态性。
J Biol Chem. 2014 Nov 14;289(46):32131-32143. doi: 10.1074/jbc.M114.594846. Epub 2014 Oct 3.