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机器人手术与腹腔镜全直肠系膜切除术治疗直肠癌的短期和长期疗效:一项病例匹配的回顾性研究。

Short and long-term outcomes of robotic versus laparoscopic total mesorectal excision for rectal cancer: a case-matched retrospective study.

作者信息

Cho Min Soo, Baek Se Jin, Hur Hyuk, Min Byung Soh, Baik Seung Hyuk, Lee Kang Young, Kim Nam Kyu

机构信息

From the Department of Surgery, Division of Colon and Rectal surgery, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Medicine (Baltimore). 2015 Mar;94(11):e522. doi: 10.1097/MD.0000000000000522.

Abstract

The true benefits of robotic surgery are controversial, and whether robotic total mesorectal excision (R-TME) can be justified as a standard treatment for rectal cancer patients needs to be clarified. This case-matched study aimed to compare the postoperative complications and short- and long-term outcomes of R-TME and laparoscopic TME (L-TME) for rectal cancer.Among 1029 patients, we identified 278 rectal cancer patients who underwent R-TME. Propensity score matching was used to match this group with 278 patients who underwent L-TME.The mean follow-up period was similar between both groups (L-TME vs R-TME: 52.5 ± 17.1 vs 51.0 ± 13.1 months, P = 0.253), as were patient characteristics. The operation time was significantly longer in the R-TME group than in the L-TME group (361.6 ± 91.9 vs 272.4 ± 83.8 min; P < 0.001), whereas the conversion rate, length of hospital stay, and recovery of pain and bowel motility were similar between both groups. The rates of circumferential resection margin involvement and early complications were similar between both groups (L-TME vs R-TME: 4.7% vs 5.0%, P = 1.000; and 23.7% vs 25.9%, P = 0.624, respectively), as were the 5-year overall survival, disease-free survival, and local recurrence rates (93.1% vs 92.2%, P = 0.422; 79.6% vs 81.8%, P = 0.538; 3.9% vs 5.9%, P = 0.313, respectively).The oncologic quality, short- and long-term outcomes, and postoperative morbidity in the R-TME group were comparable with those in the L-TME group.

摘要

机器人手术的真正益处存在争议,机器人全直肠系膜切除术(R-TME)能否作为直肠癌患者的标准治疗方法仍有待明确。本病例对照研究旨在比较R-TME与腹腔镜全直肠系膜切除术(L-TME)治疗直肠癌的术后并发症及短期和长期疗效。在1029例患者中,我们确定了278例行R-TME的直肠癌患者。采用倾向评分匹配法将该组患者与278例行L-TME的患者进行匹配。两组的平均随访时间相似(L-TME组与R-TME组:52.5±17.1个月 vs 51.0±13.1个月,P = 0.253),患者特征也相似。R-TME组的手术时间显著长于L-TME组(361.6±91.9分钟 vs 272.4±83.8分钟;P < 0.001),而两组的转化率、住院时间以及疼痛和肠道蠕动恢复情况相似。两组的环周切缘受累率和早期并发症发生率相似(L-TME组与R-TME组:分别为4.7% vs 5.0%,P = 1.000;23.7% vs 25.9%,P = 0.624),5年总生存率、无病生存率和局部复发率也相似(分别为93.1% vs 92.2%,P = 0.422;79.6% vs 81.8%,P = 0.538;3.9% vs 5.9%,P = 0.313)。R-TME组的肿瘤学质量、短期和长期疗效以及术后发病率与L-TME组相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31c3/4602485/c55b890d2fb6/medi-94-e522-g001.jpg

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