Fanelli Francesca, Chiara Matteo, Liuzzi Vania C, Haidukowski Miriam, Tristezza Mariana, Caterina Manzari, D'Erchia Anna Maria, Pesole Graziano, Horner David S, Mule Giuseppina
Institute of Sciences of Food Production, National Research Council, Bari, 70126, Italy.
Dipartimento di Bioscienze, Università degli Studi di Milano, Milan, 20133, Italy Institute of Biomembranes and Bioenergetics, National Research Council, Bari, 70126, Italy.
FEMS Microbiol Lett. 2015 Apr;362(7). doi: 10.1093/femsle/fnv004. Epub 2015 Jan 18.
Ochratoxin A (OTA) is a nephrotoxic and potentially carcinogenic mycotoxin produced by several species of Aspergillus and Penicillium. It is one of the major mycotoxins contaminating grain, grapes and a variety of food products, and the development of methods for reducing pre- and post-harvest contamination has drawn considerable attention. In the current study, we isolated and sequenced the genome of a novel free-living Acinetobacter strain able to degrade OTA. Biochemical studies suggest that the degradation reaction proceeds via peptide bond hydrolysis.
赭曲霉毒素A（OTA）是一种由几种曲霉属和青霉属真菌产生的具有肾毒性且有潜在致癌性的霉菌毒素。它是污染谷物、葡萄及多种食品的主要霉菌毒素之一，开发减少收获前和收获后污染的方法已引起了广泛关注。在本研究中，我们分离并测序了一种能够降解OTA的新型自由生活不动杆菌菌株的基因组。生化研究表明，降解反应是通过肽键水解进行的。
