Ekimoto H, Aikawa M, Ohnuki T, Takahashi K, Matsuda A, Takita T, Umezawa H
J Antibiot (Tokyo). 1985 Jan;38(1):94-8. doi: 10.7164/antibiotics.38.94.
Pulmonary fibrosis in mice induced by peplomycin (PEP) was suppressed by administration of anti-inflammatory agents such as prednisolone and D-penicillamine during or after the administration of PEP. Pulmonary fibrosis was also suppressed by administration of cyclophosphamide, an immunosuppressive antitumor agent before, during or after the administration of PEP. The pulmonary fibrosis in athymic nude mice induced by PEP was less than that in normal mice. The low response in the nude mice was enhanced by transfer of thymocytes to the same level as that in the normal mice. This suggests that the immune system, especially thymus-dependent immunity, is involved in the pulmonary fibrosis induced by PEP.
在用培普利霉素（PEP）诱导小鼠发生肺纤维化期间或之后，给予泼尼松龙和D-青霉胺等抗炎药可抑制肺纤维化。在给予PEP之前、期间或之后给予免疫抑制抗肿瘤药环磷酰胺，也可抑制肺纤维化。PEP诱导的无胸腺裸鼠的肺纤维化程度低于正常小鼠。将胸腺细胞转移至裸鼠后，其低反应性增强至与正常小鼠相同的水平。这表明免疫系统，尤其是胸腺依赖性免疫，参与了PEP诱导的肺纤维化过程。
