骨髓增生异常综合征中的粒细胞和单核细胞表面膜标志物
Granulocyte and monocyte surface membrane markers in the myelodysplastic syndromes.
作者信息
Clark R E, Hoy T G, Jacobs A
出版信息
J Clin Pathol. 1985 Mar;38(3):301-4. doi: 10.1136/jcp.38.3.301.
Abstract
The expression of lineage specific surface antigens on granulocytes and monocytes was quantitated using monoclonal antibodies in 16 healthy adults and 21 patients with myelodysplastic syndromes. In nine of 19 patients the granulocytes showed a decrease in myeloid or an increase in monocyte antigen expression or both. In 11 of 19 patients the monocytes showed a decreased expression of monocyte antigens or an increase in myeloid antigens or both. The data suggest that in the myelodysplastic syndromes the granulocyte-macrophage progenitors do not develop along two divergent lines but differentiate with the emergence of dual characteristics.
摘要
使用单克隆抗体对16名健康成年人和21名骨髓增生异常综合征患者的粒细胞和单核细胞上谱系特异性表面抗原的表达进行了定量分析。在19名患者中的9名中，粒细胞显示髓系抗原表达减少或单核细胞抗原表达增加或两者兼有。在19名患者中的11名中，单核细胞显示单核细胞抗原表达减少或髓系抗原表达增加或两者兼有。数据表明，在骨髓增生异常综合征中，粒细胞-巨噬细胞祖细胞并非沿着两条不同的路线发育，而是随着双重特征的出现而分化。
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