Kalowska Monika, Ciepiela Olga, Kowalewski Cezary, Demkow Urszula, Schwartz Robert A, Wozniak Katarzyna
Department of Dermatology and Immunodermatology , Medical University of Warsaw, Warsaw, Poland.
Acta Derm Venereol. 2016 Feb;96(2):191-6. doi: 10.2340/00015555-2101.
Bullous pemphigoid (BP) is characterized by IgG and IgE autoantibodies to the NC16a domain of BP180. This study evaluated the correlation between body surface area (BSA), total serum IgE and enzyme-linked immunoassay (ELISA) for IgG and IgE anti-NC16a in 77 patients with BP in the active stage, and the degree of conversion to negative of the studied parameters in clinical remission. Statistically positive correlations were observed between BSA and examined parameters (correlation index 0.2548, 0.2491, 0.311, respectively). Originally, patients with BP with positive ELISAs for both IgG and IgE autoantibodies presented twice as extensive skin lesions as those with positive IgG and negative IgE ELISAs. Conversion of ELISAs for IgG and IgE to negative in clinical remission occurred in 9.3% and 81% of patients with BP, respectively. This confirmed that ELISA for IgE anti-NC16a is a helpful parameter in the modification of current treatment and the assessment of risk of relapse in BP.
大疱性类天疱疮（BP）的特征是存在针对BP180的NC16a结构域的IgG和IgE自身抗体。本研究评估了77例活动期BP患者的体表面积（BSA）、血清总IgE以及IgG和IgE抗NC16a酶联免疫吸附测定（ELISA）之间的相关性，以及临床缓解期研究参数的转阴程度。观察到BSA与检测参数之间存在统计学上的正相关（相关指数分别为0.2548、0.2491、0.311）。最初，IgG和IgE自身抗体ELISA均为阳性的BP患者皮肤病变范围是IgG ELISA阳性而IgE ELISA阴性患者的两倍。临床缓解期，BP患者中IgG和IgE ELISA转阴的比例分别为9.3%和81%。这证实了IgE抗NC16a ELISA在调整当前治疗方案及评估BP复发风险方面是一个有用的参数。
