基于生物学的苯并吡喃并[3,4-c]吡咯烷的合成。
Biology-oriented synthesis of benzopyrano[3,4-c]pyrrolidines.
作者信息
Potowski Marco, Golz Christopher, Strohmann Carsten, Antonchick Andrey P, Waldmann Herbert
机构信息
Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany; Chemical Biology, Faculty of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Strasse 6, 44221 Dortmund, Germany.
Inorganic Chemistry, Faculty of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Strasse 6, 44221 Dortmund, Germany.
出版信息
Bioorg Med Chem. 2015 Jun 15;23(12):2895-903. doi: 10.1016/j.bmc.2015.02.044. Epub 2015 Mar 4.
A natural product inspired synthesis of 6,6,5-tricyclic compounds via a silver(I)-catalyzed formal 1,3-dipolar cycloaddition of coumarins with α-iminoesters was developed. The reaction proceeds in a stepwise reaction course under formation of the trans-substituted diastereomer with respect to the 1,3-dipole and shows a broad substrate scope.
通过银（I）催化香豆素与α-亚氨基酯的形式1,3-偶极环加成反应，开发了一种受天然产物启发的6,6,5-三环化合物的合成方法。该反应在相对于1,3-偶极体形成反式取代非对映异构体的情况下以逐步反应过程进行，并且显示出广泛的底物范围。
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