Højland Chris R, Andersen Hjalte H, Poulsen Jeppe N, Arendt-Nielsen Lars, Gazerani Parisa
Center for Sensory-Motor Interaction (SMI), Department of Health science and Technology, Aalborg University, Aalborg, Denmark.
Acta Derm Venereol. 2015 Sep;95(7):798-803. doi: 10.2340/00015555-2103.
The thermoreceptive transient receptor potential ankyrin 1 (TRPA1) is important in the transmission of itch, and its agonist trans-cinnamaldehyde has occasionally been reported to be a pruritogen in humans. However, no studies have accurately quantified the capabilities of trans-cinnamaldehyde to induce itch and related dysesthetic sensations. The present study examined alterations in somatosensory and vasomotor parameters in response to topical trans-cinnamaldehyde 5% and vehicle (ethanol) in 24 healthy subjects. During the study the following parameters were recorded: itch area and intensity, hyperknesis, alloknesis, neurogenic flare, skin blood flow and temperature. Trans-cinnamaldehyde evoked moderate itch sensation, flare, hyperknesis and alloknesis (p < 0.001). Blood flow and skin temperature were elevated in the area of trans-cinnamaldehyde application (p < 0.001). Significant positive correlations were found between blood flow and skin temperature, itch area and blood flow, and itch area and skin temperature. Topical trans-cinnamaldehyde proved feasible as a human itch model with applicability in studying itch mechanisms or anti-pruritic drug profiling.
热感受性瞬时受体电位锚蛋白1（TRPA1）在瘙痒传递中起重要作用，其激动剂反式肉桂醛偶尔被报道为人类的致痒原。然而，尚无研究准确量化反式肉桂醛诱发瘙痒及相关感觉异常的能力。本研究检测了24名健康受试者在局部应用5%反式肉桂醛和赋形剂（乙醇）后体感和血管运动参数的变化。研究期间记录了以下参数：瘙痒面积和强度、运动亢进、感觉异常、神经源性潮红、皮肤血流量和温度。反式肉桂醛诱发了中度瘙痒感、潮红、运动亢进和感觉异常（p < 0.001）。在应用反式肉桂醛的区域，血流量和皮肤温度升高（p < 0.001）。发现血流量与皮肤温度、瘙痒面积与血流量以及瘙痒面积与皮肤温度之间存在显著正相关。局部应用反式肉桂醛被证明是一种可行的人类瘙痒模型，适用于研究瘙痒机制或抗瘙痒药物分析。
