Weng Hao-Jui, Pham Quoc Thao Trang, Chang Chia-Wei, Tsai Tsen-Fang
Department of Dermatology, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan.
Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Pharmaceuticals (Basel). 2022 Jul 19;15(7):892. doi: 10.3390/ph15070892.
Pain and itch are both important manifestations of various disorders, such as herpes zoster, atopic dermatitis, and psoriasis. Growing evidence suggests that both sensations have shared mediators, overlapping neural circuitry, and similarities in sensitization processes. In fact, pain and itch coexist in some disorders. Determining pharmaceutical agents and targets for treating pain and itch concurrently is of scientific and clinical relevance. Here we review the neurobiology of pain and itch and discuss the pharmaceutical targets as well as novel compounds effective for the concurrent treatment of these sensations.
疼痛和瘙痒都是多种疾病的重要表现，如带状疱疹、特应性皮炎和银屑病。越来越多的证据表明，这两种感觉具有共同的介质、重叠的神经回路以及致敏过程中的相似性。事实上，在某些疾病中疼痛和瘙痒并存。确定同时治疗疼痛和瘙痒的药物制剂和靶点具有科学和临床意义。在此，我们综述疼痛和瘙痒的神经生物学，并讨论药物靶点以及对同时治疗这些感觉有效的新型化合物。
