Krajewski A S, Guy K, Dewar A E, Cossar D
J Pathol. 1985 Feb;145(2):185-94. doi: 10.1002/path.1711450206.
Twenty cases of B-cell non-Hodgkin's lymphoma (NHL) were evaluated by immunohistochemical staining of frozen sections with a panel of anti MHC class II monoclonal antibodies (MCA). These studies showed marked differences in the expression of class II antigens both between different cases and within the population of cells of individual cases. In all of the cases studied the majority of the tumour cells reacted with MCAs directed against determinants common to the products of SB and DR loci. However, MCAs specific for DC determinants failed to react with 3/20 cases and in several other cases stained only a minority of cells. Absent or reduced expression of DC antigens was most marked in lymphocytic lymphoma; however, in centroblastic-centrocytic and centroblastic lymphomas, DC antigens could be detected on the majority of cells.
应用一组抗MHC II类单克隆抗体（MCA）对20例B细胞非霍奇金淋巴瘤（NHL）的冰冻切片进行免疫组织化学染色评估。这些研究显示，II类抗原的表达在不同病例之间以及单个病例的细胞群体中均存在显著差异。在所研究的所有病例中，大多数肿瘤细胞与针对SB和DR基因座产物共有的决定簇的MCA发生反应。然而，针对DC决定簇的特异性MCA未能与20例中的3例发生反应，在其他几例中仅对少数细胞进行染色。DC抗原表达缺失或减少在淋巴细胞性淋巴瘤中最为明显；然而，在中心母细胞-中心细胞性淋巴瘤和中心母细胞性淋巴瘤中，大多数细胞上均可检测到DC抗原。
