Hansson G K, Jonasson L, Holm J, Claesson-Welsh L
Clin Exp Immunol. 1986 May;64(2):261-8.
Class II antigens of the major histocompatibility complex (MHC) are normally expressed only by cells of the immune system. They may, however, also appear on other cells, both in vivo and in vitro. We have studied class II MHC antigen expression on human arterial smooth muscle cells using immunocytochemical analysis of surgical biopsies. The class II antigens, HLA-DQ and HLA-DR are virtually absent from cells of normal arteries, but appear in atherosclerotically transformed tissue, where the majority of cells express HLA-DR, and one-third of the cells express HLA-DQ. These atherosclerotic plaques are composed of a heterogeneous population of cells, which includes smooth muscle cells, macrophages, and T cells. Among smooth muscle cells containing the muscle-specific intermediate filament protein desmin, one-third of the cells express HLA-DR and almost as many express HLA-DQ. These cells also contain the invariant gamma chain, which is associated with class II antigens during intracellular transport. Plaque macrophages, in contrast, are usually of the DQ-DR+ phenotype. The patterns of class II antigen expression are discussed in relation to cell differentiation and pathogenesis of disease.
主要组织相容性复合体（MHC）的II类抗原通常仅由免疫系统的细胞表达。然而，它们也可能在体内和体外的其他细胞上出现。我们使用手术活检的免疫细胞化学分析方法，研究了人类动脉平滑肌细胞上II类MHC抗原的表达情况。正常动脉细胞中几乎不存在II类抗原HLA-DQ和HLA-DR，但在动脉粥样硬化转变的组织中会出现，其中大多数细胞表达HLA-DR，三分之一的细胞表达HLA-DQ。这些动脉粥样硬化斑块由多种异质性细胞组成，包括平滑肌细胞、巨噬细胞和T细胞。在含有肌肉特异性中间丝蛋白结蛋白的平滑肌细胞中，三分之一的细胞表达HLA-DR，几乎同样数量的细胞表达HLA-DQ。这些细胞还含有恒定的γ链，其在细胞内运输过程中与II类抗原相关。相比之下，斑块巨噬细胞通常具有DQ-DR +表型。本文讨论了II类抗原表达模式与细胞分化和疾病发病机制的关系。
