趋化因子控制着动脉粥样硬化中单核细胞的动员、募集和命运。
Chemokines control mobilization, recruitment, and fate of monocytes in atherosclerosis.
机构信息
From the Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany (M.D., J.D., O.S.); Department of Pathology, Academic Medical Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands (M.D., O.S.); and German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany (M.D., O.S.).
出版信息
Arterioscler Thromb Vasc Biol. 2015 May;35(5):1050-5. doi: 10.1161/ATVBAHA.114.304649. Epub 2015 Mar 19.
Atherosclerosis is a chronic inflammatory disease of large arteries and, among others, characterized by continuous influx of monocytes into the subendothelial space, subsequent macrophage accumulation, and foam cell formation. Chemokines and their receptors tightly orchestrate monocyte trafficking and fate from birth to death. This brief review summarizes our current understanding of the interplay between monocytes and chemokines entertaining crucial processes in atherosclerosis development, progression, and regression.
动脉粥样硬化是一种慢性大动脉炎症性疾病，其特征是单核细胞不断涌入血管内皮下腔，随后巨噬细胞聚集和泡沫细胞形成。趋化因子及其受体紧密协调单核细胞从出生到死亡的迁移和命运。这篇简短的综述总结了我们目前对单核细胞和趋化因子相互作用的理解，这些作用涉及动脉粥样硬化发展、进展和消退过程中的关键过程。
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