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去甲肾上腺素对大鼠额叶皮质轴突终末产生广泛影响的证据。

Evidence for widespread effects of noradrenaline on axon terminals in the rat frontal cortex.

作者信息

Mobley P, Greengard P

出版信息

Proc Natl Acad Sci U S A. 1985 Feb;82(3):945-7. doi: 10.1073/pnas.82.3.945.

DOI:10.1073/pnas.82.3.945
PMID:2579383
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC397164/
Abstract

Noradrenaline, apparently working through activation of beta-adrenergic receptors, alters the state of phosphorylation of a substantial proportion of synapsin I in rat frontal cortex. Since synapsin I is enriched in virtually all axon terminals in this brain region, the results indicate that noradrenaline, a sparsely distributed neurotransmitter, affects a large number of axon terminals in this region. The results also suggest that noradrenaline receptors are present on a substantial percentage of all axon terminals in the cerebral cortex, despite the low density of noradrenergic fibers present. The data support the view that noradrenaline may serve a paracrine function.

摘要

去甲肾上腺素显然是通过激活β-肾上腺素能受体发挥作用，它改变了大鼠额叶皮质中相当一部分突触素I的磷酸化状态。由于突触素I几乎在该脑区的所有轴突终末中都有富集，这些结果表明，去甲肾上腺素这种分布稀疏的神经递质会影响该区域的大量轴突终末。结果还表明，尽管去甲肾上腺素能纤维密度较低，但大脑皮质中相当比例的轴突终末上都存在去甲肾上腺素受体。这些数据支持了去甲肾上腺素可能具有旁分泌功能这一观点。

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本文引用的文献

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Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes.突触素I（蛋白I），一种神经末梢特异性磷蛋白。II. 通过免疫细胞化学在琼脂糖包埋的突触体中证明其与突触小泡的特异性结合。
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Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections.突触素I（蛋白I），一种神经末梢特异性磷蛋白。I. 通过冷冻切片和塑料切片免疫荧光法显示其在中枢和外周神经系统突触中的总体分布。
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Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases.环磷酸腺苷依赖性蛋白激酶和钙依赖性蛋白激酶对纯化蛋白I多个位点的差异磷酸化作用。
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Noradrenergic axon terminals in the cerebral cortex of rat. II. Quantitative data revealed by light and electron microscope radioautography of the frontal cortex.大鼠大脑皮质中的去甲肾上腺素能轴突终末。II. 额叶皮质光镜和电镜放射自显影显示的定量数据。
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