去甲肾上腺素对大鼠额叶皮质轴突终末产生广泛影响的证据。
Evidence for widespread effects of noradrenaline on axon terminals in the rat frontal cortex.
作者信息
Mobley P, Greengard P
出版信息
Proc Natl Acad Sci U S A. 1985 Feb;82(3):945-7. doi: 10.1073/pnas.82.3.945.
Abstract
Noradrenaline, apparently working through activation of beta-adrenergic receptors, alters the state of phosphorylation of a substantial proportion of synapsin I in rat frontal cortex. Since synapsin I is enriched in virtually all axon terminals in this brain region, the results indicate that noradrenaline, a sparsely distributed neurotransmitter, affects a large number of axon terminals in this region. The results also suggest that noradrenaline receptors are present on a substantial percentage of all axon terminals in the cerebral cortex, despite the low density of noradrenergic fibers present. The data support the view that noradrenaline may serve a paracrine function.
摘要
去甲肾上腺素显然是通过激活β-肾上腺素能受体发挥作用，它改变了大鼠额叶皮质中相当一部分突触素I的磷酸化状态。由于突触素I几乎在该脑区的所有轴突终末中都有富集，这些结果表明，去甲肾上腺素这种分布稀疏的神经递质会影响该区域的大量轴突终末。结果还表明，尽管去甲肾上腺素能纤维密度较低，但大脑皮质中相当比例的轴突终末上都存在去甲肾上腺素受体。这些数据支持了去甲肾上腺素可能具有旁分泌功能这一观点。
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