Chen Lizhang, Li Zhanzhan, Li Yanyan, Xue Jing, Chen Peng, Yan Shipeng, Jiang Caixiao, Hu Yingyun, Qiao Xing
Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
Department of emergency, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, China.
PLoS One. 2015 Mar 20;10(3):e0120300. doi: 10.1371/journal.pone.0120300. eCollection 2015.
Left ventricular hypertrophy (LVH) was suggested to be an important risk factor for hypertensive vascular complications. Previous studies had also shown that red cell distribution width (RDW) was associated with morbidity and mortality of cardiovascular disease. However, few have yet investigated possible association between RDW and LVH. The aim of the present study was to evaluate the relationship between LVH and RDW levels in hypertensive patients.
Physical examination, laboratory tests and echocardiography were conducted in 330 untreated newly diagnosed hypertensive patients attending the cardiology consultation unit at the Anzhen Hospital of Beijing. The multivariate logistic regression model was used to verify the independent association between RDW and LVH.
174 patients without LVH and 156 patients with LVH were rolled in the study. The patients with LVH had higher mean SBP, albumin to creatinine ratio, total cholesterol, RDW and fasting glucose compared with non-LVH group. The mean HDL-cholesterol level was significantly lower in patients with LVH than patients without LVH. The multiple logistic regression model suggested that patients with a higher RDW level were more likely to be LVH (OR=2.187, 95%CI: 1.447-3.307, P<0.001). Other predictive factors for LVH were mean SBP, serum creatinine, glucose level. The receiver operating characteristics (ROC) curves indicated area under the curve was 0.688(95%CI: 0.635-0.737, P<0.001) with a cut-off value of 12.9, the RDW predicted LVH status among hypertensive patients with a sensitivity of 72.4% and a specificity of 60.3%.
The higher RDW level was observed in the LVH group compared with the non-LVH group. RDW might be associated with LVH in hypertensive patients. These data highlight the role of RDW as a predictor of organ damage in essential hypertensive patients.
左心室肥厚（LVH）被认为是高血压血管并发症的重要危险因素。先前的研究还表明，红细胞分布宽度（RDW）与心血管疾病的发病率和死亡率相关。然而，很少有人研究RDW与LVH之间可能存在的关联。本研究的目的是评估高血压患者中LVH与RDW水平之间的关系。
对北京安贞医院心内科门诊330例未经治疗的新诊断高血压患者进行体格检查、实验室检查和超声心动图检查。采用多因素逻辑回归模型验证RDW与LVH之间的独立关联。
本研究纳入174例无LVH患者和156例有LVH患者。与无LVH组相比，有LVH组患者的平均收缩压、白蛋白与肌酐比值、总胆固醇、RDW和空腹血糖更高。有LVH组患者的平均高密度脂蛋白胆固醇水平显著低于无LVH组患者。多因素逻辑回归模型显示，RDW水平较高的患者更易发生LVH（OR=2.187，95%CI：1.447-3.307，P<0.001）。LVH的其他预测因素为平均收缩压、血清肌酐、血糖水平。受试者工作特征（ROC）曲线显示曲线下面积为0.688（95%CI：0.635-0.737，P<0.001），截断值为12.9，RDW预测高血压患者LVH状态的灵敏度为72.4%，特异度为60.3%。
与无LVH组相比，LVH组的RDW水平更高。RDW可能与高血压患者的LVH相关。这些数据凸显了RDW作为原发性高血压患者器官损害预测指标的作用。
