Zhou Tao, Chen Xiaofang, Li Zhanzhan, Li Lezhi
Department of Cardiology, the Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Xiangya Nursing School, Central South University, Changsha, Hunan Province, China and Nursing Department, The Third Affiliated Hostipal Of Southern Medical Universtiy, Guangzhou, Guangdong Province, China.
PLoS One. 2015 Apr 27;10(4):e0125275. doi: 10.1371/journal.pone.0125275. eCollection 2015.
Prospective studies have found low bilirubin levels were an important predictive factor of cardiovascular events. However, few have yet investigated possible association between serum bilirubin level and LVH in essential hypertension. The aim of the present study was to evaluate the relationship between serum bilirubin levels with LVH in newly diagnosed hypertension patients.
The present study evaluated the relationship between serum total bilirubin level and left ventricle hypertrophy (LVH) in newly diagnosed hypertensive patients with a sample size of 344. We divided subjects into LVH group (n=138) and non-LVH group (n=206). Physical examination, laboratory tests and echocardiography were conducted. The multivariate logistic regression model was used to verify the independent association between RDW and LVH.
Our results found that patients with LVH had lower bilirubin levels than non-LVH ones. Stepwise multiple linear regression analysis showed total bilirubin level (B=-0.017, P=0.008) was negatively associated with left ventricle mass index (LVMI) even adjusting for some confounders. The multiples logistic regression found total bilirubin level was independently related with of LVH, as a protective factors (OR=0.91, P=0.010).
As a routine and quick laboratory examination index, serum bilirubin may be treated as novel marker for evaluating LVH risk in hypertensive patients. Cohort study with larger sample size are needed.
前瞻性研究发现低胆红素水平是心血管事件的重要预测因素。然而，很少有研究探讨血清胆红素水平与原发性高血压左心室肥厚（LVH）之间的可能关联。本研究的目的是评估新诊断高血压患者血清胆红素水平与LVH之间的关系。
本研究评估了344例新诊断高血压患者的血清总胆红素水平与左心室肥厚（LVH）之间的关系。我们将受试者分为LVH组（n = 138）和非LVH组（n = 206）。进行了体格检查、实验室检查和超声心动图检查。采用多因素logistic回归模型验证红细胞分布宽度（RDW）与LVH之间的独立关联。
我们的结果发现，LVH患者的胆红素水平低于非LVH患者。逐步多元线性回归分析显示，即使校正了一些混杂因素，总胆红素水平（B = -0.017，P = 0.008）与左心室质量指数（LVMI）呈负相关。多因素logistic回归发现总胆红素水平与LVH独立相关，作为保护因素（OR = 0.91，P = 0.010）。
作为一项常规且快速的实验室检查指标，血清胆红素可作为评估高血压患者LVH风险的新型标志物。需要进行更大样本量的队列研究。
