Comstock Sarah S, Xu Diana, Hortos Kari, Kovan Bruce, McCaskey Sarah, Pathak Dorothy R, Fenton Jenifer I
aDepartment of Food Science and Human Nutrition bCollege of Osteopathic Medicine cDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing dTri-County Gastroenterology, Charter Township of Clinton, Michigan, USA.
Eur J Cancer Prev. 2016 May;25(3):173-81. doi: 10.1097/CEJ.0000000000000160.
Chronic inflammation contributes to colorectal carcinogenesis. To determine whether serum cytokines are associated with colon polyps, 126 asymptomatic men (48-65 years) were recruited during colonoscopy. Serum cytokine concentrations were measured. Odds ratios were determined using polytomous logistic regression for polyp number and type. Men with serum monocyte chemotactic protein-3 (MCP-3) or soluble interleukin-4 receptor (sIL-4R) concentrations in the highest tertile were 0.2 times less likely to have three or more polyps relative to no polyps. For each increase in serum MCP-3 or sIL-4R tertile a man was about 0.4 times less likely to have three or more polyps than to have no polyps. Men with serum concentrations of interferon-α2 (IFN-α2) or interleukin (IL)-7 in the highest tertile were three times more likely to have an adenoma than no polyps. Those with serum IL-8 concentrations in the highest tertile were four times more likely to have an adenoma than no polyps. For each increase in serum IFN-α2, IL-7, or IL-8 tertile an individual was 1.8 times more likely to have an adenoma than to have no polyps. Serum concentrations of MCP-3, sIL-4R, IFN-α2, IL-7, and IL-8 may indicate which men are more likely to have colorectal polyps.
慢性炎症与结直肠癌的发生有关。为了确定血清细胞因子是否与结肠息肉相关，在结肠镜检查期间招募了126名无症状男性（48 - 65岁）。测量血清细胞因子浓度。使用多分类逻辑回归确定息肉数量和类型的优势比。血清单核细胞趋化蛋白-3（MCP-3）或可溶性白细胞介素-4受体（sIL-4R）浓度处于最高三分位数的男性，相对于无息肉者，有三个或更多息肉的可能性低0.2倍。男性血清MCP-3或sIL-4R每升高一个三分位数，其有三个或更多息肉的可能性比无息肉者低约0.4倍。血清干扰素-α2（IFN-α2）或白细胞介素（IL）-7浓度处于最高三分位数的男性患腺瘤的可能性是无息肉者的三倍。血清IL-8浓度处于最高三分位数的男性患腺瘤的可能性是无息肉者的四倍。血清IFN-α2、IL-7或IL-8每升高一个三分位数，个体患腺瘤的可能性比无息肉者高1.8倍。血清MCP-3、sIL-4R、IFN-α2、IL-7和IL-8的浓度可能表明哪些男性更有可能患有结肠息肉。
