Comstock Sarah S, Lewis Markita M, Pathak Dorothy R, Hortos Kari, Kovan Bruce, Fenton Jenifer I
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, United States of America.
Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, United States of America.
PLoS One. 2014 Apr 16;9(4):e95232. doi: 10.1371/journal.pone.0095232. eCollection 2014.
Diverticulosis can lead to diverticulitis, a colon condition involving inflammation and other complications. Diverticulosis can result from biological, behavioral, or genetic causes. However, the etiology of diverticulosis is unknown. Although diet is associated with diverticulosis, recent studies suggest other factors influence risk. We sought to identify anthropometric or serum markers that were associated with the presence of diverticulosis. To determine these associations, 126 asymptomatic men (48-65 yr) were recruited at the time of preventative screening colonoscopy. Anthropometric measures were taken, and blood was collected for serum protein analysis. Data were analyzed by logistic regression and factor analysis. Obese individuals (BMI >30) were 7.8 (CI: 2.3-26.3) times more likely than normal weight (BMI <25) individuals to have diverticulosis. The relationship was similar for waist circumference. Individuals with a waist circumference >45 inches were 8.1 (CI: 2.8-23.8) times more likely to have diverticulosis than those with a waist circumference <38 inches. Leptin was also positively associated with diverticulosis (OR = 5.5, CI: 2.0-14.7). Both low molecular weight adiponectin (LMW, OR = 0.50; CI: 0.3-0.8) and the soluble receptor for advanced glycation end products (sRAGE, OR = 0.4, CI: 0.3-0.7) were inversely related to the presence of diverticulosis. sRAGE levels were not correlated with leptin or C-peptide concentrations. The pattern of high BMI, waist circumference, leptin and C-peptide increased the odds of diverticulosis while the pattern of high levels of sRAGE and LMW adiponectin decreased the odds of diverticulosis. Associations between diverticulosis and anthropometric or serum markers may elucidate the origins of diverticulosis and may enable physicians to identify individuals at risk for diverticulitis.
憩室病可导致憩室炎，这是一种涉及结肠炎症及其他并发症的病症。憩室病可能由生物学、行为或遗传因素引起。然而，憩室病的病因尚不清楚。虽然饮食与憩室病有关，但最近的研究表明其他因素也会影响患病风险。我们试图确定与憩室病存在相关的人体测量指标或血清标志物。为了确定这些关联，在预防性结肠镜检查时招募了126名无症状男性（48 - 65岁）。进行了人体测量，并采集血液进行血清蛋白分析。数据通过逻辑回归和因子分析进行分析。肥胖个体（BMI>30）患憩室病的可能性是正常体重个体（BMI<25）的7.8倍（CI：2.3 - 26.3）。腰围的情况类似。腰围>45英寸的个体患憩室病的可能性是腰围<38英寸个体的8.1倍（CI：2.8 - 23.8）。瘦素也与憩室病呈正相关（OR = 5.5，CI：2.0 - 14.7）。低分子量脂联素（LMW，OR = 0.50；CI：0.3 - 0.8）和晚期糖基化终产物可溶性受体（sRAGE，OR = 0.4，CI：0.3 - 0.7）均与憩室病的存在呈负相关。sRAGE水平与瘦素或C肽浓度无关。高BMI、腰围、瘦素和C肽的模式增加了患憩室病的几率，而高sRAGE和LMW脂联素水平的模式则降低了患憩室病的几率。憩室病与人体测量指标或血清标志物之间的关联可能有助于阐明憩室病的起源，并可能使医生能够识别出有憩室炎风险的个体。
