Loeschner Katrin, Navratilova Jana, Grombe Ringo, Linsinger Thomas P J, Købler Carsten, Mølhave Kristian, Larsen Erik H
Division of Food Chemistry, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark.
Division of Food Chemistry, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark.
Food Chem. 2015 Aug 15;181:78-84. doi: 10.1016/j.foodchem.2015.02.033. Epub 2015 Feb 14.
Nanomaterials are increasingly used in food production and packaging, and validated methods for detection of nanoparticles (NPs) in foodstuffs need to be developed both for regulatory purposes and product development. Asymmetric flow field-flow fractionation with inductively coupled plasma mass spectrometric detection (AF(4)-ICP-MS) was applied for quantitative analysis of silver nanoparticles (AgNPs) in a chicken meat matrix following enzymatic sample preparation. For the first time an analytical validation of nanoparticle detection in a food matrix by AF(4)-ICP-MS has been carried out and the results showed repeatable and intermediately reproducible determination of AgNP mass fraction and size. The findings demonstrated the potential of AF(4)-ICP-MS for quantitative analysis of NPs in complex food matrices for use in food monitoring and control. The accurate determination of AgNP size distribution remained challenging due to the lack of certified size standards.
纳米材料在食品生产和包装中的应用日益广泛，出于监管目的和产品开发需求，需要开发经过验证的食品中纳米颗粒（NPs）检测方法。采用酶促样品前处理后，将不对称流场-流分馏与电感耦合等离子体质谱检测（AF(4)-ICP-MS）联用，对鸡肉基质中的银纳米颗粒（AgNPs）进行定量分析。首次对AF(4)-ICP-MS检测食品基质中纳米颗粒进行了分析验证，结果表明AgNP质量分数和尺寸的测定具有可重复性和中等再现性。研究结果证明了AF(4)-ICP-MS在复杂食品基质中用于食品监测和控制的纳米颗粒定量分析的潜力。由于缺乏经认证的尺寸标准，准确测定AgNP尺寸分布仍然具有挑战性。
