Munday John S, French Adrienne F
Department of Pathobiology, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand.
New Zealand Veterinary Pathology Ltd, Palmerston North, New Zealand.
Res Vet Sci. 2015 Jun;100:220-2. doi: 10.1016/j.rvsc.2015.03.002. Epub 2015 Mar 6.
Oral squamous cell carcinomas (OSCCs) are common feline cancers. Why OSCCs are so common in cats is unknown; however, 25% of human OSCCs are caused by papillomaviruses (PVs). Two feline oral PVs (FcaPV-1 and 4) are recognized. As PVs are highly host and location specific, if PVs do cause feline OSCCs, FcaPV-1 and 4 are the most likely etiological agents. PCR primers specific for FcaPV-1 amplified DNA from 1 of 36 feline OSCCs and 1 of 16 inflammatory oral lesions. No DNA was amplified by primers specific for FcaPV-4. PV DNA was not amplified from any additional sample using consensus primers. No PV cytopathology was visible in the OSCC that contained FcaPV-1 DNA, but viral cytopathology was present in a focus of epithelial hyperplasia in the non-neoplastic sample. This study does not support a PV etiology of feline OSCCs, but shows that FcaPV-1 can asymptomatically infect the mouth of cats.
口腔鳞状细胞癌（OSCC）是猫常见的癌症。OSCC在猫中如此常见的原因尚不清楚；然而，25%的人类OSCC是由乳头瘤病毒（PV）引起的。已识别出两种猫口腔PV（FcaPV - 1和4）。由于PV具有高度的宿主和位置特异性，如果PV确实导致猫OSCC，那么FcaPV - 1和4是最可能的病原体。针对FcaPV - 1的特异性PCR引物从36例猫OSCC中的1例以及16例炎性口腔病变中的1例扩增出了DNA。针对FcaPV - 4的引物未扩增出DNA。使用通用引物未从任何其他样本中扩增出PV DNA。在含有FcaPV - 1 DNA的OSCC中未观察到PV细胞病理学特征，但在非肿瘤性样本的上皮增生灶中存在病毒细胞病理学特征。本研究不支持猫OSCC的PV病因，但表明FcaPV - 1可无症状感染猫的口腔。
