Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Expert Rev Proteomics. 2015 Apr;12(2):185-96. doi: 10.1586/14789450.2015.1024228.
Although proteomics has been exploited in a wide range of diseases for identification of biomarkers and pathophysiological mechanisms, there are still biomedical disciplines such as otology where proteomics platforms are underused due to technical challenges and/or complex features of the disease. Thus, in the past few years, healthcare and scientific agencies have advocated the development and adoption of proteomic technologies in otological research. However, few studies have been conducted and limited literature is available in this area. Here, we present the state of the art of proteomics in otology, discussing the substantial evidence from recent experimental models and clinical studies in inner-ear conditions. We also delineate a series of critical issues including minute size of the inner ear, delicacy and poor accessibility of tissue that researchers face while undertaking otology proteomics research. Furthermore, we provide perspective to enhance the impact and lead to the clinical implementation of these proteomics-based strategies.
尽管蛋白质组学已广泛应用于多种疾病，以鉴定生物标志物和病理生理机制，但仍有一些医学学科，如耳科学，由于技术挑战和/或疾病的复杂特征，蛋白质组学平台的应用不足。因此，在过去几年中，医疗保健和科学机构一直倡导在耳科学研究中开发和采用蛋白质组学技术。然而，在这一领域进行的研究很少，相关文献也有限。在这里，我们介绍了耳科学中的蛋白质组学的最新进展，讨论了来自内耳疾病的最近实验模型和临床研究的大量证据。我们还阐述了一系列关键问题，包括内耳的微小尺寸、组织的精细和难以接近，这些问题是研究人员在进行耳科学蛋白质组学研究时面临的。此外，我们还提供了一些观点，以增强这些基于蛋白质组学的策略的影响力，并促使其在临床上得到应用。
