Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, E-28871 Alcalá de Henares, Spain.
Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, E-28871 Alcalá de Henares, Spain; Advanced Study Institute of Madrid, IMDEA-Agua, Parque Científico Tecnológico, E-28805 Alcalá de Henares, Spain.
J Hazard Mater. 2015 Jul 15;292:34-43. doi: 10.1016/j.jhazmat.2015.02.075. Epub 2015 Feb 28.
The continuous ozonation of the antibiotic ofloxacin (OFX) has been performed using a synthetic water matrix and in a sewage treatment plant (STP) effluent. The aim was to study the effect of the water matrix on the ozonation with particular emphasis on the aquatic toxicity of treated water. OFX was completely removed in both water matrices, although the amount of ozone consumed for its depletion was strongly matrix-dependent. The extent of mineralization was limited and a number of intermediate transformation products (TPs) appeared, twelve of which could be identified. OFX reaction pathway includes the degradation of piperazinyl and quinolone moieties. The further oxidation of TPs gave rise to the formation and accumulation of carboxylic acids, aldehydes, nitrogen-containing organic compounds and inorganic ions. Aquatic toxicity of treated mixtures was assessed using four standard species: the bacteria Vibrio fischeri and Pseudomonas putida as target organisms and the algae Pseudokirchneriella subcapitata and the protozoan Tetrahymena thermophila as non-target organisms. OFX was toxic for the bacteria and the microalgae at the spiked concentration in untreated water. However, the continuous ozonation at the upper operational limit removed its toxic effects. T. thermophila was not affected by OFX, but was sensitive to STP effluent.
采用合成水基质和污水处理厂（STP）出水连续对抗生素氧氟沙星（OFX）进行臭氧化处理。目的是研究水基质对臭氧化的影响，特别强调处理水的水生毒性。OFX 在两种水基质中均被完全去除，尽管其消耗的臭氧量强烈依赖于基质。矿化程度有限，出现了一些中间转化产物（TPs），其中 12 种可以被鉴定。OFX 的反应途径包括哌嗪基和喹诺酮部分的降解。TPs 的进一步氧化导致羧酸、醛、含氮有机化合物和无机离子的形成和积累。采用四种标准物种评估处理混合物的水生毒性：细菌发光杆菌和假单胞菌作为靶生物，以及藻类新月菱形藻和原生动物嗜热四膜虫作为非靶生物。在未处理水中，OFX 对细菌和微藻具有毒性。然而，在上限操作条件下连续臭氧化去除了其毒性。T. thermophila 不受 OFX 的影响，但对 STP 出水敏感。
