Suman Thodhal-Yoganandham, Kim Soo-Yeon, Yeom Dong-Hyuk, Jeon Junho
Department of Environmental Engineering, Changwon National University, Changwon 51140, Gyeongsangnam-do, Korea.
School of Smart and Green Engineering, Changwon National University, Changwon 51140, Gyeongsangnam-do, Korea.
Toxics. 2022 Jan 24;10(2):54. doi: 10.3390/toxics10020054.
The scientific community has increasingly focused on forming transformation products (TPs) from environmental organic pollutants. However, there is still a lot of discussion over how these TPs are generated and how harmful they are to living terrestrial or aquatic organisms. Potential transformation pathways, TP toxicity, and their mechanisms require more investigation. Non-target screening (NTS) via high-resolution mass spectrometry (HRMS) in model organisms to identify TPs and the formation mechanism on various organisms is the focus of this review. Furthermore, uptake, accumulation process, and potential toxicity with their detrimental consequences are summarized in various organisms. Finally, challenges and future research initiatives, such as performing NTS in a model organism, characterizing and quantifying TPs, and evaluating future toxicity studies on TPs, are also included in this review.
科学界越来越关注环境有机污染物形成的转化产物（TPs）。然而，关于这些TPs是如何产生的以及它们对陆地或水生生物有多大危害，仍存在诸多讨论。潜在的转化途径、TP毒性及其机制需要更多研究。通过在模式生物中使用高分辨率质谱（HRMS）进行非靶标筛查（NTS）以识别TPs及其在各种生物中的形成机制是本综述的重点。此外，还总结了各种生物中的吸收、积累过程以及潜在毒性及其有害后果。最后，本综述还包括了一些挑战和未来的研究倡议，例如在模式生物中进行NTS、表征和量化TPs，以及评估未来关于TPs的毒性研究。
