Environmental Research Group, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Environmental Research Group, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Sci Total Environ. 2015 Jul 1;520:23-31. doi: 10.1016/j.scitotenv.2015.03.033. Epub 2015 Mar 16.
Application of ozonation in water treatment involves complex oxidation pathways that could lead to the formation of various by-products, some of which may be harmful to living organisms. In this work, ozonation by-products of ofloxacin (OFX), a frequently detected pharmaceutical pollutant in the environment, were identified and their ecotoxicity was estimated using the Ecological Structure Activity Relationships (ECOSAR) computer program. In order to examine the role of ozone (O3) and hydroxyl radicals (∙OH) in the degradation of ofloxacin, ozonation was performed at pH2, 7 and 12. In this study, 12 new structures have been proposed for the ozonation by-products detected during the ozonation of ofloxacin. According to the identified ozonation by-products, O3 and ∙OH were found to react with ofloxacin during ozonation. The reaction between ofloxacin and O3 proceeded via hydroxylation and breakdown of heterocyclic ring with unsaturated double-bond. The reaction between ofloxacin and ·OH generated various by-products derived from the breakdown of heterocyclic ring. Ecotoxicity assessment indicated that ozonation of OFX could yield by-products of greater toxicity compared with parent compounds.
臭氧氧化在水处理中的应用涉及复杂的氧化途径，可能导致各种副产物的形成，其中一些可能对生物体有害。在这项工作中，鉴定了环境中经常检测到的药物污染物氧氟沙星（OFX）的臭氧氧化副产物，并使用生态结构活性关系（ECOSAR）计算机程序估算了它们的生态毒性。为了研究臭氧（O3）和羟基自由基（·OH）在氧氟沙星降解中的作用，在 pH2、7 和 12 下进行了臭氧氧化。在这项研究中，提出了在氧氟沙星的臭氧氧化过程中检测到的 12 种新的臭氧氧化副产物结构。根据鉴定出的臭氧氧化副产物，发现臭氧和·OH在臭氧氧化过程中与氧氟沙星发生反应。氧氟沙星与 O3 的反应通过杂环的羟基化和不饱和双键的断裂进行。氧氟沙星与·OH 的反应生成了各种源自杂环断裂的副产物。生态毒性评估表明，与母体化合物相比，臭氧氧化 OFX 可能产生毒性更大的副产物。
