Fraczek Monika, Kurpisz Maciej
Department of Reproductive Biology and Stem Cells, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
J Reprod Immunol. 2015 Apr;108:98-104. doi: 10.1016/j.jri.2015.02.001. Epub 2015 Feb 28.
Cell integration between the immune and reproductive systems is the basis for normal male reproductive physiology. Cytokines are a part of the autocrine/paracrine network operating in the male reproductive tract. At the same time, immunological reactions occurring via cytokines appear to be both beneficial and/or risk factors for male fertility. As the cytokines are produced by a whole spectrum of cells in all compartments of the male genital tract, they can also be involved in a variety of andrological disorders. The monitoring of cytokines and other immune factors in seminal plasma may offer a chance to better understand the mechanisms leading to sub-/infertility. In this review, we present insights into cytokine interplay in some of the pathological conditions associated with male reproduction.
免疫和生殖系统之间的细胞整合是正常男性生殖生理学的基础。细胞因子是男性生殖道中自分泌/旁分泌网络的一部分。同时，通过细胞因子发生的免疫反应似乎既是男性生育能力的有益因素和/或风险因素。由于细胞因子由男性生殖道所有区域的各种细胞产生，它们也可能参与多种男科疾病。监测精浆中的细胞因子和其他免疫因子可能为更好地理解导致亚不育/不育的机制提供机会。在本综述中，我们阐述了与男性生殖相关的一些病理状况下细胞因子相互作用的见解。
