Wang Peng, Duan Yong-Gang
Department of Urology, Daping Hospital, Institute of Surgery Research, The Third Military Medical University, Chongqing, China.
Centre of Reproductive Medicine and Andrology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Am J Reprod Immunol. 2016 Sep;76(3):186-92. doi: 10.1111/aji.12536. Epub 2016 Jun 29.
Dendritic cells (DCs) are the most potent professional antigen-presenting cells. The central role of various DC subsets as bridges between innate and adaptive immunity has become more and more evident. However, the role of DC subsets in male reproductive tract remains largely unexplored, in particular distinct DC subsets (including myeloid and plasmacytoid DCs), their maturation stage, and tissue distribution, as well as state of health or disease. Furthermore, infection and inflammation of male genital tract are thought to be a primary etiological factor of male infertility. This review sheds some light on this complex and rapidly growing field. It summarized the recent findings and deals with the characterization and role of DCs in male reproductive tract, that is, testis, epididymis, prostate, seminal vesicle, semen, and foreskin, which might help to understand the immunopathological mechanisms of male infertility and design effective vaccines for male reproductive health.
树突状细胞（DCs）是最强大的专职抗原呈递细胞。各种DC亚群作为固有免疫和适应性免疫之间的桥梁所发挥的核心作用已越来越明显。然而，DC亚群在男性生殖道中的作用在很大程度上仍未得到探索，尤其是不同的DC亚群（包括髓样和浆细胞样DCs）、它们的成熟阶段、组织分布以及健康或疾病状态。此外，男性生殖道的感染和炎症被认为是男性不育的主要病因。这篇综述为这个复杂且快速发展的领域提供了一些见解。它总结了最近的研究发现，并探讨了DCs在男性生殖道（即睾丸、附睾、前列腺、精囊、精液和包皮）中的特征和作用，这可能有助于理解男性不育的免疫病理机制，并为男性生殖健康设计有效的疫苗。
