无精子症和严重少弱畸精子症患者精液中的白细胞介素-6

Interleukin-6 in Seminal Plasmas of Azoospermic and Severe Oligo-Astheno-Teratozoospermic Patients.

作者信息

Azil Soukaina, Mbaye Modou Mamoune, Jelloul Hasnaa, Benkhalifa Moncef, Louanjli Noureddine, Ghazi Bouchra

机构信息

Immunopathology-Immunotherapy-Immunomonitoring Laboratory, Mohammed VI University of Sciences and Health, Casablanca 82403, Morocco.

Laboratory of Medical Analysis and Reproductive Biology, Labomac, Casablanca, Morocco.

出版信息

Iran J Public Health. 2025 Mar;54(3):624-633. doi: 10.18502/ijph.v54i3.18256.

DOI:10.18502/ijph.v54i3.18256

PMID:40330195

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12051803/

Abstract

BACKGROUND

The IL-6 levels in seminal plasma have an important impact on sperm quality. This study aimed to evaluate the correlation between IL-6 levels in seminal plasma and sperm parameters for Moroccan population.

METHODS

This is a case control study. Semen samples were obtained from patients who consulted the Medical Analysis Laboratory and Reproductive Biology Labomac, Casablanca, Morocco from Apr 2022 to Jun 2023, among them 50 presenting azoospermia, 25 severe oligo-astheno-teratozoospermia and 25 normozoospermia.

RESULTS

Significant differences regarding age of azoospermic patients (=0.008) and BMI for OATS and azoospermic (=0.032, =0.047 respectively), also for physical activity azoospermic <0.01 and =0.02 for OATS patients same difference for micronutrient intake especially for zinc. Sperm parameters present also statistically significant in terms of motility, concentration, and morphology ( < 0.05). Semen interleukin-6 levels showed a significant difference for azoospermic patients (=0.045) also for OATS (=0.001). On the other hand, leucoscreen analysis revealed a significantly higher mean leukocytes concentration in azoospermic and OATS patients =0.004 and <0.001 respectively).

CONCLUSION

The seminal plasma IL-6 assay could be used as a sensitive biomarker of silent infection or inflammation of the male genital tract.

摘要

背景

精浆中的白细胞介素-6（IL-6）水平对精子质量有重要影响。本研究旨在评估摩洛哥人群精浆中IL-6水平与精子参数之间的相关性。

方法

这是一项病例对照研究。精液样本取自2022年4月至2023年6月在摩洛哥卡萨布兰卡的医学分析实验室和生殖生物学实验室Labomac就诊的患者，其中50例无精子症，25例严重少弱畸精子症，25例正常精子症。

结果

无精子症患者的年龄（=0.008）、少弱畸精子症和无精子症患者的体重指数（分别为=0.032和=0.047）存在显著差异，无精子症患者的体力活动（<0.01）和少弱畸精子症患者的体力活动（=0.02）也存在显著差异，微量营养素摄入尤其是锌的差异相同。精子参数在活力、浓度和形态方面也具有统计学意义（<0.05）。精液白细胞介素-6水平在无精子症患者中（=0.045）和少弱畸精子症患者中（=0.001）也显示出显著差异。另一方面，白细胞筛查分析显示无精子症和少弱畸精子症患者的平均白细胞浓度显著更高（分别为=0.004和<0.001）。