Oneglia C, Fabris C, Modica A, Rossi C M, Bigo P, Ricco G
Boll Soc Ital Biol Sper. 1984 Feb 28;60(2):421-7.
The Authors refer that the oxygen affinity, determined by double tonometry, in normal adult whole blood, is mainly expressed by a P50 of 26.13 +/- 4.31% and by an n factor of 2.63 +/- 6.63%. These results are in good agreement with those reported in the literature, but here are some doubts that pO2 and SO2 alone, i.e. the data drawn from all the tonometric procedures, can give a full idea of the affinity. In fact, this one is a complicate process, modulated by a number of allosteric effectors. Most of them, like pH, temperature and pCO2 can be always kept at a fixed standard level, whereas DPG, the main one, cannot.
作者指出，通过双血气分析法测定的正常成人全血中的氧亲和力，主要表现为P50为26.13±4.31%，n因子为2.63±6.63%。这些结果与文献报道的结果高度一致，但有人质疑仅pO2和SO2，即所有血气分析程序得出的数据，能否全面反映亲和力。事实上，这是一个复杂的过程，受多种变构效应剂调节。其中大多数，如pH、温度和pCO2可以始终保持在固定的标准水平，而主要的效应剂2,3-二磷酸甘油酸（DPG）则不能。
